Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

374 questions · 393 findings · 47 reviews · Headline outcomes only

No studies found 73 · 18.6%GRADE not reported 16 · 4.1%Very low 164 · 41.7%Low 85 · 21.6%Moderate 36 · 9.2%High 19 · 4.8%

Closed‐system transfer device plus safe handling vs safe handling alone

Cyclophosphamide or ifosfamide · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes cyclophosphamide or ifosfamide compared with safe handling alone (very low certainty).

1 finding from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

Ifosfamide · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes ifosfamide compared with safe handling alone (very low certainty).

1 finding from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

Methotrexate · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes methotrexate compared with safe handling alone (very low certainty).

1 finding from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

5‐fluorouracil · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes 5‐fluorouracil compared with safe handling alone (very low certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Rubella cases Initial meta‐analysis ‐ clinical diagnosis or serology +/‐ virus isolation +/‐ clinical signs · susceptible people exposed to rubella

Gamma‐globulin probably leads to lower rubella cases Initial meta‐analysis ‐ clinical diagnosis or serology… compared with control (saline or no treatment) (moderate certainty).

1 finding from 1 review