Findings

What do systematic reviews say?

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

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No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Uterine artery embolization (UAE) vs surgery

Satisfaction with treatment up to 24 months · patients with symptomatic uterine fibroids

Uterine artery embolization (UAE) showed no clear difference in satisfaction with treatment up to 24 months compared with surgery (moderate certainty).

1 finding from 1 review

Uterine artery embolization for symptomatic uterine fibroids 2014 · Cochrane Headline outcomes only
OR 0.94 [0.59, 1.48]
6 studies · 640 participants
Moderate

Uterine artery embolization (UAE) vs surgery

Satisfaction with treatment at 5 years · patients with symptomatic uterine fibroids

Uterine artery embolization (UAE) showed no clear difference in satisfaction with treatment at 5 years compared with surgery (moderate certainty).

1 finding from 1 review

Uterine artery embolization for symptomatic uterine fibroids 2014 · Cochrane Headline outcomes only
OR 0.9 [0.45, 1.8]
2 studies · 295 participants
Moderate

Uterine artery embolization (UAE) vs surgery

Live birth · patients with symptomatic uterine fibroids

It is very uncertain whether uterine artery embolization (UAE) changes live birth ‐ UAE versus myomectomy compared with surgery (very low certainty).

1 finding from 1 review

Uterine artery embolization for symptomatic uterine fibroids 2014 · Cochrane Headline outcomes only
OR 0.26 [0.08, 0.84]
1 study · 66 participants
Very low

Uterine artery embolization (UAE) vs surgery

Adverse events: intra‐procedural complications · patients with symptomatic uterine fibroids

Uterine artery embolization (UAE) showed no clear difference in adverse events: intra‐procedural complications compared with surgery (low certainty).

1 finding from 1 review

Uterine artery embolization for symptomatic uterine fibroids 2014 · Cochrane Headline outcomes only
OR 0.91 [0.42, 1.97]
4 studies · 452 participants
Low

Uterine artery embolization (UAE) vs surgery

Adverse events: minor post‐procedural complications within one year · patients with symptomatic uterine fibroids

Uterine artery embolization (UAE) probably leads to higher adverse events: minor post‐procedural complications within one year compared with surgery (moderate certainty).

1 finding from 1 review

Uterine artery embolization for symptomatic uterine fibroids 2014 · Cochrane Headline outcomes only
OR 1.99 [1.41, 2.81]
6 studies · 735 participants
Moderate

Uterine artery embolization (UAE) vs surgery

Adverse events: major post‐procedural complications within one year · patients with symptomatic uterine fibroids

Uterine artery embolization (UAE) showed no clear difference in adverse events: major post‐procedural complications within one year compared with surgery (moderate certainty).

1 finding from 1 review

Uterine artery embolization for symptomatic uterine fibroids 2014 · Cochrane Headline outcomes only
OR 0.65 [0.33, 1.26]
5 studies · 611 participants
Moderate

Uterine artery embolization (UAE) vs surgery

Further interventions within 2 years · patients with symptomatic uterine fibroids

Uterine artery embolization (UAE) probably leads to higher further interventions within 2 years compared with surgery (moderate certainty).

1 finding from 1 review

Uterine artery embolization for symptomatic uterine fibroids 2014 · Cochrane Headline outcomes only
OR 3.72 [2.28, 6.04]
6 studies · 732 participants
Moderate

Local anaesthetic wound infiltration before incision vs end of surgery

All‐cause mortality · patients with people undergoing laparoscopic cholecystectomy

1 finding from 1 review

Wound infiltration with local anaesthetic agents for laparoscopic cholecystectomy 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 43 participants
Very low

Local anaesthetic wound infiltration before incision vs end of surgery

Serious adverse events · patients with people undergoing laparoscopic cholecystectomy

1 finding from 1 review

Wound infiltration with local anaesthetic agents for laparoscopic cholecystectomy 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 43 participants
Very low

Local anaesthetic wound infiltration before incision vs end of surgery

Pain 4 to 8 hours · patients with people undergoing laparoscopic cholecystectomy

1 finding from 1 review

Wound infiltration with local anaesthetic agents for laparoscopic cholecystectomy 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 76 participants
Very low

Local anaesthetic wound infiltration before incision vs end of surgery

Pain 9 to 24 hours · patients with people undergoing laparoscopic cholecystectomy

1 finding from 1 review

Wound infiltration with local anaesthetic agents for laparoscopic cholecystectomy 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Local anaesthetic wound infiltration before incision vs end of surgery

Return to normal activity · patients with people undergoing laparoscopic cholecystectomy

1 finding from 1 review

Wound infiltration with local anaesthetic agents for laparoscopic cholecystectomy 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Balloon sensory training biofeedback vs surgery

Number improved at one year · Patients with anismus and chronic constipation

It is very uncertain whether balloon sensory training biofeedback changes number improved at one year compared with surgery (very low certainty).

1 finding from 1 review

Biofeedback for treatment of chronic idiopathic constipation in adults 2014 · Cochrane Headline outcomes only
RR 0.43 [0.21, 0.89]
1 study · 40 participants
Very low

Balloon sensory training biofeedback vs surgery

Constipation score at one year · Patients with anismus and chronic constipation

1 finding from 1 review

Biofeedback for treatment of chronic idiopathic constipation in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Epidural anaesthesia in addition to general anaesthesia vs general anaesthesia

Death from all causes Range of · patients undergoing primary tumour surgery

Epidural anaesthesia in addition to general anaesthesia showed no clear difference in death from all causes Range of compared with general anaesthesia alone (low certainty).

1 finding from 1 review

Anaesthetic techniques for risk of malignant tumour recurrence 2014 · Cochrane Headline outcomes only
HR 1.03 [0.86, 1.24]
3 studies · 647 participants
Low

Epidural anaesthesia in addition to general anaesthesia vs general anaesthesia

Tumour progression or death from all causes Range of · patients undergoing primary tumour surgery

It is very uncertain whether epidural anaesthesia in addition to general anaesthesia changes tumour progression or death from all causes Range of compared with general anaesthesia alone (very low certainty).

1 finding from 1 review

Anaesthetic techniques for risk of malignant tumour recurrence 2014 · Cochrane Headline outcomes only
HR 0.88 [0.56, 1.38]
2 studies · 535 participants
Very low

Epidural anaesthesia in addition to general anaesthesia vs general anaesthesia

Tumour progression Median · patients undergoing primary tumour surgery

It is very uncertain whether epidural anaesthesia in addition to general anaesthesia changes tumour progression Median compared with general anaesthesia alone (very low certainty).

1 finding from 1 review

Anaesthetic techniques for risk of malignant tumour recurrence 2014 · Cochrane Headline outcomes only
HR 1.5 [1, 2.25]
2 studies · 545 participants
Very low

Nalbuphine vs placebo

Number of patients with moderate/severe pain (1 hour postoperatively) · children undergoing surgery

Nalbuphine may leads to lower number of patients with moderate/severe pain (1 hour postoperatively) compared with placebo (low certainty).

2 findings from 1 review

Nalbuphine for postoperative pain treatment in children 2014 · Cochrane Headline outcomes only
RR 0.1 [0.01, 0.71]
1 study · 40 participants
Low
Nalbuphine for postoperative pain treatment in children 2014 · Cochrane Headline outcomes only
RR 0.14 [0.02, 1.06]
1 study · 40 participants
Low

Nalbuphine vs morphine

Number of patients with postoperative nausea and vomiting (postoperative care unit) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with postoperative nausea and vomiting… compared with morphine (low certainty).

1 finding from 1 review

Nalbuphine for postoperative pain treatment in children 2014 · Cochrane Headline outcomes only
RR 1.33 [0.64, 2.77]
2 studies · 90 participants
Low

Nalbuphine vs morphine

Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with postoperative nausea and vomiting (24 hours… compared with morphine (low certainty).

1 finding from 1 review

Nalbuphine for postoperative pain treatment in children 2014 · Cochrane Headline outcomes only
RR 1.2 [0.8, 1.8]
1 study · 50 participants
Low