Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Tramadol vs pethidine

Additional analgesia required (escape analgesia) · children undergoing surgery

It is very uncertain whether tramadol changes number of patients requiring rescue analgesia (PACU) compared with pethidine (very low certainty).

1 finding from 1 review

Tramadol vs pethidine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

Tramadol showed no clear difference in number of patients with moderate to severe pain (PACU) compared with pethidine (low certainty).

1 finding from 1 review

Tramadol vs pethidine

Number of patients with PONV (PACU) · children undergoing surgery

Tramadol showed no clear difference in number of patients with PONV (PACU) compared with pethidine (low certainty).

1 finding from 1 review

Tramadol vs fentanyl

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs placebo

Number of patients with PONV (PACU) · children undergoing surgery

Tramadol showed no clear difference in number of patients with PONV (PACU) compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol vs placebo

Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · children undergoing surgery

Tramadol showed no clear difference in number of patients with PONV (24 hours postoperatively) compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol vs morphine

Additional analgesia required (escape analgesia) · children undergoing surgery

Tramadol showed no clear difference in number of patients requiring rescue analgesia (PACU) compared with morphine (low certainty).

2 findings from 1 review

Tramadol vs morphine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs nalbuphine

Additional analgesia required (escape analgesia) · children undergoing surgery

It is very uncertain whether tramadol changes number of patients requiring rescue analgesia (24 hours… compared with nalbuphine (very low certainty).

1 finding from 1 review