Findings

What do systematic reviews say?

3,234 questions · 3,357 findings · 396 reviews

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No studies found 803 · 23.9%GRADE not reported 270 · 8%Very low 757 · 22.5%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Intervention not reported

Failure of normalisation of ALT at end of treatment · patients with chronic hepatitis C.

It is very uncertain whether the intervention changes failure of normalisation of ALT at end of treatment (very low certainty).

1 finding from 1 review

Aminoadamantanes versus other antiviral drugs for chronic hepatitis C 2014 · Cochrane Headline outcomes only
RR 2.02 [1.07, 3.82]
1 study · 29 participants
Very low

Intervention not reported

Failure of normalisation of ALT at end of · patients with chronic hepatitis C.

It is very uncertain whether the intervention changes failure of normalisation of ALT at end of (very low certainty).

1 finding from 1 review

Aminoadamantanes versus other antiviral drugs for chronic hepatitis C 2014 · Cochrane Headline outcomes only
RR 1.31 [1.05, 1.63]
2 studies · 92 participants
Very low

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Proportion of patients with >50% maximum pain relief (TOTPAR) over 2 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Combined paracetamol plus ibuprofen in a single tablet (e.g.… showed no clear difference in proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
2 hours postdosing · Paracetamol 1000 mg/ibuprofen 400 mg vs paracetamol 1000 mg or ibuprofen 400 mg
RR 1.29 [0.91, 1.85]
1 study · 170 participants
Moderate

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Adverse events · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
Study period (immediate postoperative)
The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
2 studies
GRADE not reported

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Participant‐reported pain relief of 50% or greater · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Combined paracetamol plus ibuprofen in a single tablet (e.g.… probably leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
6 hours postdosing · Paracetamol 1000 mg/ibuprofen 400 mg vs paracetamol 1000 mg or ibuprofen 400 mg
RR 1.77 [1.32, 2.39]
1 study · 170 participants
Moderate

Hepatic resection vs radiofrequency ablation

Overall survival · 578 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 578 participants
Moderate

Percutaneous ethanol injection vs radiofrequency ablation

Local progression · 1088 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 678 participants
Moderate

Percutaneous ethanol injection vs radiofrequency ablation

Rate of complications · 1088 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1088 participants
Moderate

Percutaneous ethanol injection vs radiofrequency ablation

Length of hospital stay · 1088 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 576 participants
Moderate

Hepatic resection vs radiofrequency ablation

2‐year survival‐ · 578 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 578 participants
Moderate

Hepatic resection vs radiofrequency ablation

Event‐free survival · 578 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 578 participants
Moderate

Hepatic resection vs radiofrequency ablation

Local progression · 578 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 168 participants
Low

Hepatic resection vs radiofrequency ablation

Rate of complications · 578 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 578 participants
High

Hepatic resection vs radiofrequency ablation

Length of hospital stay · 578 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 578 participants
High

Percutaneous ethanol injection vs radiofrequency ablation

Overall survival · 1088 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1088 participants
Moderate

Percutaneous ethanol injection vs radiofrequency ablation

2‐year survival · 1088 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 715 participants
Moderate

Percutaneous ethanol injection vs radiofrequency ablation

Event‐free survival · 1088 patients with early HCC

1 finding from 1 review

Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma 2013 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 949 participants
Moderate

Intervention not reported

Pain free response at 2 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Headache relief at 1 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low