Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

592 questions · 604 findings · 53 reviews · Headline outcomes only

No studies found 151 · 25%GRADE not reported 31 · 5.1%Very low 94 · 15.6%Low 170 · 28.1%Moderate 114 · 18.9%High 44 · 7.3%

Chemotherapy alone vs same chemotherapy plus radiotherapy

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early and advanced stages)

Chemotherapy alone may leads to lower secondary malignant neoplasms compared with same chemotherapy plus radiotherapy (low certainty).

1 finding from 1 review

Fewer vs more courses of chemotherapy (with or without radiotherapy

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early stages)

Fewer showed no clear difference in secondary malignant neoplasms compared with more courses of chemotherapy (with or without radiotherapy (moderate certainty).

1 finding from 1 review

Fewer vs more courses of chemotherapy (with or without radiotherapy

Death · Patients with untreated Hodgkin lymphoma (early stages)

Fewer showed no clear difference in death compared with more courses of chemotherapy (with or without radiotherapy (high certainty).

1 finding from 1 review

Fewer vs more courses of chemotherapy (with or without radiotherapy

Progression/relapse · Patients with untreated Hodgkin lymphoma (early stages)

Fewer showed no clear difference in progression/relapse compared with more courses of chemotherapy (with or without radiotherapy (high certainty).

1 finding from 1 review

Dose‐intensified chemotherapy vs ABVD‐like chemotherapy (with or without radiotherapy

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (advanced stages)

Dose‐intensified chemotherapy showed no clear difference in secondary malignant neoplasms compared with ABVD‐like chemotherapy (with or without radiotherapy (low certainty).

1 finding from 1 review

Dose‐intensified chemotherapy vs ABVD‐like chemotherapy (with or without radiotherapy

Death · Patients with untreated Hodgkin lymphoma (advanced stages)

Dose‐intensified chemotherapy showed no clear difference in death compared with ABVD‐like chemotherapy (with or without radiotherapy (moderate certainty).

1 finding from 1 review

Dose‐intensified chemotherapy vs ABVD‐like chemotherapy (with or without radiotherapy

Progression/relapse · Patients with untreated Hodgkin lymphoma (advanced stages)

Dose‐intensified chemotherapy probably leads to lower progression/relapse compared with ABVD‐like chemotherapy (with or without radiotherapy (moderate certainty).

1 finding from 1 review

Chemotherapy alone vs same chemotherapy plus radiotherapy

Death · Patients with untreated Hodgkin lymphoma (early and advanced stages)

Chemotherapy alone showed no clear difference in death compared with same chemotherapy plus radiotherapy (moderate certainty).

1 finding from 1 review

Chemotherapy alone vs same chemotherapy plus radiotherapy

Progression/relapse · Patients with untreated Hodgkin lymphoma (early and advanced stages)

Chemotherapy alone showed no clear difference in progression/relapse compared with same chemotherapy plus radiotherapy (moderate certainty).

1 finding from 1 review

Boost vs no boost

Disease-free survival (new disease, progression or mortality) · breast‐conserving radiotherapy for breast cancer

Boost showed no clear difference in disease‐free survival: disease progression/mortality at 5 years compared with no boost (low certainty).

1 finding from 1 review

Boost vs no boost

Cosmesis · breast‐conserving radiotherapy for breast cancer

Boost may leads to higher cosmesis, panel scored: fair or poor compared with no boost (low certainty).

2 findings from 1 review

Boost vs no boost

Subgroup analysis: local control ‐ > 40 years old, recurrence at 5 years · breast‐conserving radiotherapy for breast cancer

Boost leads to lower subgroup analysis: local control ‐ > 40 years old, recurrence at 5… compared with no boost (high certainty).

1 finding from 1 review