Cochrane · systematic review · CD011987
Tumour bed boost radiotherapy for women after breast‐conserving surgery
Kindts, I, Laenen, A, Depuydt, T, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 25%Low 3 · 37.5%Moderate 1 · 12.5%High 2 · 25%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Boost compared to no boost in breast cancer radiotherapy
Population: breast‐conserving radiotherapy for breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Local control: recurrence at 5 years Boost vs no boost | HR 0.64 [0.55, 0.75] | 5 studies · 8315 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Overall survival: mortality at 5 years Boost vs no boost | HR 1.04 [0.94, 1.14] | 2 studies · 6342 participants | Moderate Downgraded: imprecision |
Disease‐free survival: disease progression/mortality at 5 years Boost vs no boost | HR 0.94 [0.87, 1.02] | 3 studies · 6549 participants | Low Downgraded: imprecision, inconsistency |
Late toxicity, pBRA Boost vs no boost | MD 0.38 | 2 studies · 1526 participants | Very low Downgraded: imprecision, inconsistency |
Cosmesis, panel scored: fair or poor Boost vs no boost | OR 1.41 [1.07, 1.85] | 2 studies · 1116 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Cosmesis, physician‐scored: fair or poor Boost vs no boost | OR 1.58 [0.93, 2.69] | 2 studies · 592 participants | Very low Downgraded: risk of bias, imprecision |
Sensitivity analysis: local control ‐ recurrence at 5 years Boost vs no boost | HR 0.62 [0.52, 0.73] | 3 studies · 6963 participants | High |
Subgroup analysis: local control ‐ > 40 years old, recurrence at 5 years Boost vs no boost | HR 0.65 [0.53, 0.81] | 2 studies · 5058 participants | High |