Findings

What do systematic reviews say?

359 questions · 378 findings · 47 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 90 · 23.8%GRADE not reported 58 · 15.3%Very low 80 · 21.2%Low 104 · 27.5%Moderate 37 · 9.8%High 9 · 2.4%

Prefabricated foot orthoses vs shoes

Function or disability · children with asymptomatic flat feet

The review found no eligible studies for this question.

1 finding from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Treatment failure day‐28 PCR‐adjusted(PP population) · children aged 14 years or younger with uncomplicated P falciparum malaria

The intervention showed no clear difference in treatment failure day‐28 PCR‐adjusted(PP population) (low certainty).

1 finding from 1 review

Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children 2020 · Cochrane Headline outcomes only
RR 1.35 [0.49, 3.72]
2 studies · 1061 participants
Low

Intervention not reported

Treatment failureday‐28 PCR‐adjusted(ITT population) · children aged 14 years or younger with uncomplicated P falciparum malaria

The intervention showed no clear difference in treatment failureday‐28 PCR‐adjusted(ITT population) (low certainty).

1 finding from 1 review

Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children 2020 · Cochrane Headline outcomes only
RR 1.05 [0.68, 1.62]
2 studies · 1139 participants
Low

Intervention not reported

Serious adverse events · children aged 14 years or younger with uncomplicated P falciparum malaria

The intervention showed no clear difference in serious adverse events (low certainty).

1 finding from 1 review

Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children 2020 · Cochrane Headline outcomes only
RR 1.05 [0.38, 2.88]
2 studies · 1197 participants
Low

Intervention not reported

Drug‐related adverse events · children aged 14 years or younger with uncomplicated P falciparum malaria

The intervention probably leads to lower drug‐related adverse events (moderate certainty).

1 finding from 1 review

Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children 2020 · Cochrane Headline outcomes only
RR 0.78 [0.62, 0.99]
2 studies · 1197 participants
Moderate

Intervention not reported

Drug‐related vomiting · children aged 14 years or younger with uncomplicated P falciparum malaria

The intervention showed no clear difference in drug‐related vomiting (low certainty).

1 finding from 1 review

Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children 2020 · Cochrane Headline outcomes only
RR 0.75 [0.56, 1.01]
2 studies · 1197 participants
Low

Intervention not reported

Acceptability · children aged 14 years or younger with uncomplicated P falciparum malaria

1 finding from 1 review

Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Any glucocorticoid vs placebo

In‐hospital postoperative mortality · Children having heart surgery with cardiopulmonary bypass

Glucocorticoid showed no clear difference in in‐hospital postoperative mortality compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
RR 0.83 [0.33, 2.07]
5 studies · 313 participants
Moderate

Any glucocorticoid vs placebo

Duration of postoperative mechanical ventilation · Children having heart surgery with cardiopulmonary bypass

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 421 participants
High

Any glucocorticoid vs placebo

Length of postoperative ICU stay · Children having heart surgery with cardiopulmonary bypass

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 421 participants
High

Any glucocorticoid vs placebo

Length of postoperative hospital stay · Children having heart surgery with cardiopulmonary bypass

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 176 participants
Moderate

Any glucocorticoid vs placebo

Mortality within the longest · Children having heart surgery with cardiopulmonary bypass

Glucocorticoid showed no clear difference in all‐cause mortality at longest compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
RR 0.83 [0.33, 2.07]
5 studies · 313 participants
Moderate

Any glucocorticoid vs placebo

Cardiovascular mortality · Children having heart surgery with cardiopulmonary bypass

Glucocorticoid showed no clear difference in cardiovascular mortality at longest compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
RR 0.4 [0.07, 2.46]
3 studies · 109 participants
Moderate

Any glucocorticoid vs placebo

Failure to separate from CPB · Children having heart surgery with cardiopulmonary bypass

Glucocorticoid showed no clear difference in failure to separate from CPB compared with placebo (low certainty).

1 finding from 1 review

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass 2020 · Cochrane Headline outcomes only
RR 0.2 [0.01, 3.92]
1 study · 40 participants
Low

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Mandibular ramus growth · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

1 finding from 1 review

Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
End of treatment (about 2 years)
The author reported no difference between groups in mandibular ramus growth (linear measure Ar-Go). No pooled estimate.
1 study
GRADE not reported

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Stability of anterior open bite correction (1 year after treatment) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
Outcome proposed in the review but not found in any included study. The review states: 'The other outcomes proposed in this review were not found: stability of anterior open bite correction; reduction of snoring; signs…
0 studies
No studies found

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Reduction or treatment of obstructive sleep apnoea syndrome (OSAS) or upper airway resistance syndrome (UARS) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
Outcome proposed in the review but not found in any included study. The review states: 'The other outcomes proposed in this review were not found: stability of anterior open bite correction; reduction of snoring; signs…
0 studies
No studies found

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Mandibular ramus growth · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

1 finding from 1 review

Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
End of treatment (12 months)
Cephalometric data (SNA, Co-A, SNB, Ar-Go, Ar.GoMe, Co-Gn, ANB) were reported to be not significantly different between groups; effects were dento-alveolar rather than skeletal. No pooled estimate (Almeida 2005).
1 study
GRADE not reported

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Alteration of hyperdivergent growth pattern · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

1 finding from 1 review

Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
End of treatment (12 months)
The angles (SN.GoGN, SN.PP, NS.Gn) and linear measures (AFA, AFP, AFAI) did not demonstrate significant alterations between groups; interventions did not produce significant changes in the skeletal maxillary or…
1 study
GRADE not reported

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Expansion of the upper and lower jaw · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

1 finding from 1 review

Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
End of treatment (12 months)
Listed among the outcome measures evaluated by Almeida 2005. No separate width/expansion estimate is reported in the text; the review concluded the interventions produced no significant change in the skeletal maxillary…
1 study
GRADE not reported