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Evidence found and GRADE certainty

4,771 questions · 10,185 findings · 893 reviews

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No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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Marine‐derived n‐3 fatty acids therapy vs No marine‐derived n‐3 fatty acids therapy

Recurrent events (both ischaemic and haemorrhagic stroke) · stroke and/or TIA

Marine‐derived n‐3 fatty acids therapy showed no clear difference in recurrent events (both ischaemic and haemorrhagic stroke) compared with no marine‐derived n‐3 fatty acids therapy (low certainty).

1 finding from 1 review

Marine‐derived n‐3 fatty acids therapy vs No marine‐derived n‐3 fatty acids therapy

Adverse events · stroke and/or TIA

Marine‐derived n‐3 fatty acids therapy showed no clear difference in adverse events compared with no marine‐derived n‐3 fatty acids therapy (low certainty).

2 findings from 1 review

Marine‐derived n‐3 fatty acids therapy vs No marine‐derived n‐3 fatty acids therapy

Recurrent events: fatal or non‐fatal (same type of stroke, i.e. ischaemic or haemorrhagic) · stroke and/or TIA

It is very uncertain whether marine‐derived n‐3 fatty acids therapy changes recurrent events: fatal or non‐fatal (same type of stroke, i.e.… compared with no marine‐derived n‐3 fatty acids therapy (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No eligible studies compared oral hairy leukoplakia between different ART regimens.

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Gingivitis · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in gingivitis between ART regimens (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

cART was associated with a significantly lower prevalence of oral candidiasis than monotherapy or dual therapy (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Persistent parotid enlargement prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in persistent parotid enlargement between ART regimens (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Major complications · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes major complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Mortality within the longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes all‐cause mortality (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Length of hospital stay · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes length of hospital stay (days) compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Surgery‐related complications (during longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Non‐surgery‐related complications (during longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes non‐surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Renal failure · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes renal failure (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review