Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

720 questions · 751 findings · 105 reviews

No studies found 193 · 25.7%GRADE not reported 37 · 4.9%Very low 212 · 28.2%Low 193 · 25.7%Moderate 99 · 13.2%High 17 · 2.3%

Counter-stimulation or distraction vs Conventional treatment

Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

Counter-stimulation or distraction led to lower pain on injection (Wong-Baker Faces / TPPPS / FPS-R, after LA) compared with conventional treatment; GRADE not reported.

1 finding from 1 review

Audiovisual distraction vs Conventional treatment

Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

Audiovisual distraction showed no clear difference in pain on injection (Wong-Baker Faces Pain Rating Scale, after… compared with conventional treatment; GRADE not reported.

1 finding from 1 review

The wand (computer-controlled LA delivery system) vs Sleeper One (electronic LA delivery system)

Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The wand (computer-controlled LA delivery system) showed no clear difference in pain on injection (self-reported; FACES Pain Scale Revised) compared with sleeper One (electronic LA delivery system); GRADE not reported.

1 finding from 1 review

Macroplastique vs dextranomer/hyaluronic acid polymer (Deflux) to correct vesicoureteric reflux

Number of kidneys with temporary renal dilatation after injection · primary VUR

Macroplastique may leads to higher number of kidneys with temporary renal dilatation after injection compared with dextranomer/hyaluronic acid polymer (Deflux) to correct… (low certainty).

1 finding from 1 review

Reminders (+/‐ educational information) vs usual family planning care

Adherence to method use as indicated by on‐time injections overall · Women of reproductive age seeking to avoid pregnancy

Reminders (+/‐ educational information) showed no clear difference in adherence to method use as indicated by on‐time injections overall compared with usual family planning care (low certainty).

1 finding from 1 review

TNF‐α blockers intervention vs placebo or additional treatment

Adverse effects after treatment initiation: injection site reactions, neutropenia, infections, demyelinating disease, heart failure, malignancy, and induction of autoimmunity. · children diagnosed with Kawasaki disease

The review found no eligible studies for this question.

1 finding from 1 review

Nonavalent HPV vaccine vs quadrivalent HPV vaccine

Overall local/injection site adverse events at 15‐day · 9‐ to 26‐year‐old females and males

Nonavalent HPV vaccine leads to higher overall local/injection site adverse events at 15‐day compared with quadrivalent HPV vaccine (high certainty).

1 finding from 1 review

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

4% articaine, 1:100,000 epinephrine vs 2% mepivacaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

4% articaine, 1:200,000 epinephrine vs 4% articaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
2 findings from 1 review

3% prilocaine, 0.03 IU felypressin vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

4% articaine, 1:200,000 epinephrine vs 0.5% bupivacaine, 1:200,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
2 findings from 1 review

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review