Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

954 questions · 963 findings · 130 reviews · Headline outcomes only

No studies found 181 · 18.8%GRADE not reported 71 · 7.4%Very low 163 · 16.9%Low 311 · 32.3%Moderate 163 · 16.9%High 74 · 7.7%

Intervention not reported

Treatment discontinuation due to adverse event (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention probably leads to lower treatment discontinuation due to adverse event (safety population) (moderate certainty).

1 finding from 1 review

Intervention not reported

Treatment‐related death (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention may leads to higher treatment‐related death (safety population) (low certainty).

1 finding from 1 review

Intervention not reported

Nausea/vomiting* grade 3 or 4 (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention may leads to higher nausea/vomiting* grade 3 or 4 (safety population) (low certainty).

1 finding from 1 review

Intervention not reported

Anaemia grade 3 or 4 (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention may leads to higher anaemia grade 3 or 4 (safety population) (low certainty).

1 finding from 1 review

Intervention not reported

Leukopaenia (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention probably leads to higher leukopaenia (safety population) (moderate certainty).

1 finding from 1 review

Intervention not reported

Any reported infant death (fetal, neonatal, or before hospital discharge · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower any reported infant death (fetal, neonatal, or before hospital… (high certainty).

1 finding from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Fetal/neonatal/infant · women with mild to moderate hypertension during pregnancy

The review found no eligible studies for this question.

2 findings from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Total reported fetal or neonatal deaths (including miscarriage) · women with mild to moderate hypertension during pregnancy

Any antihypertensive drug showed no clear difference in total reported fetal or neonatal deaths (including miscarriage) compared with no antihypertensive drugs/placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse effects experienced by mother and/or fetus or nursing baby · women with a history of postnatal depression
1 finding from 1 review

Enhancing vaccination access vs no intervention or another intervention

Home visit with encouragement to receive influenza vaccination compared to home visit with safety intervention · people aged 60 years and older living in the community

Enhancing vaccination access showed no clear difference in home visit with encouragement to receive influenza vaccination… compared with no intervention or another intervention (high certainty).

1 finding from 1 review

Upright position vs recumbent position

Abnormal fetal heart rate patterns, requiring intervention · women in the second stage of labour with epidural anaesthesia

It is very uncertain whether upright position changes abnormal fetal heart rate patterns, requiring intervention compared with recumbent position (very low certainty).

1 finding from 1 review

Metabolomics vs non metabolomics

Clinical pregnancy (Presence of a fetal heart on ultrasound scan at seven weeks of gestation) · Women undergoing IVF/ICSI cycles

Metabolomics showed no clear difference in clinical pregnancy (Presence of a fetal heart on ultrasound scan at… compared with non metabolomics (low certainty).

1 finding from 1 review