Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,324 questions · 1,405 findings · 189 reviews

No studies found 402 · 28.6%GRADE not reported 294 · 20.9%Very low 323 · 23%Low 232 · 16.5%Moderate 117 · 8.3%High 37 · 2.6%

Lamotrigine vs placebo

Any reported adverse effects 6‐12 months after initiating the intervention (long term) · bipolar disorder

Lamotrigine showed no clear difference in any reported adverse effects 6‐12 months after initiating the… compared with placebo (moderate certainty).

1 finding from 1 review

tDCS vs active control

Secondary outcome measure: lower extremity function at the end of · people with stroke
2 findings from 1 review

tDCS vs active control

Muscle strength · people with stroke
2 findings from 1 review

tDCS vs active control

Secondary outcome measure: cognitive abilities at the end of · people with stroke

The review found no eligible studies for this question.

2 findings from 1 review

tDCS vs active control

Dropouts, adverse events and deaths during intervention phase Numbers of dropouts, adverse events and deaths from all causes · people with stroke

tDCS showed no clear difference in secondary outcome measure: dropouts, adverse events and deaths… compared with any type of active control intervention (moderate certainty).

1 finding from 1 review

tDCS vs active control

ADL outcome · people with stroke

The review found no eligible studies for this question.

2 findings from 1 review

tDCS vs active control

Secondary outcome measure: mean upper extremity function at the end of the intervention periodClinical measures of upper extremity function. Scale from: 0 to infinity. · people with stroke
2 findings from 1 review

tDCS vs placebo or control

Dropouts, adverse events and deaths during intervention phase Numbers of dropouts, adverse events and deaths from all causes · people with stroke

tDCS showed no clear difference in secondary outcome measure: dropouts, adverse events and deaths… compared with any type of placebo or passive control intervention (moderate certainty).

1 finding from 1 review

Self‐administered medical abortion vs provider‐administered medical abortion

Any complication requiring surgical intervention ‐ NRSs ( · women of reproductive age (15 to 49 years) seeking induced abortion

The review found no eligible studies for this question.

2 findings from 1 review

Surgical portosystemic shunts vs devascularisation with splenectomy

Any re‐intervention · people with hepatosplenic schistosomiasis

It is very uncertain whether surgical portosystemic shunts changes any re‐intervention compared with devascularisation with splenectomy (very low certainty).

1 finding from 1 review