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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Perioperative infraorbital nerve block vs Intravenous analgesia

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) vs Conventional mechanical caries removal (standard drill; handpiece with a bur)

Participant discomfort (vibration, smell, noise) · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
1 finding from 1 review
  • Lasers for caries removal in deciduous and permanent teeth 2016 · Cochrane All outcomes
    during treatment
    Five studies reported participant discomfort (Belcheva 2014; Evans 2000; Hadley 2000; Keller 1998; Liu 2006). Keller 1998 (90 adults): discomfort significantly lower with laser (Analysis 1.6). Hadley 2000 (66 adults):…
    5 studies
    GRADE not reported

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs usual care

Oral health: Not brushing teeth twice a day · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Intermediate restorative material (IRM)

Prevalence of pain - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in prevalence of pain - 1 day compared with intermediate restorative material (IRM) (low certainty).

1 finding from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 2 days · People requiring retreatment of periapical lesions (failed root canal therapy)

Papilla base incision (PBI) showed no clear difference in postoperative pain (VAS 0-100) - 2 days compared with complete papilla mobilisation (sulcular incision); GRADE not reported.

1 finding from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether papilla base incision (PBI) changes postoperative pain (VAS 0-100) - 1 day compared with complete papilla mobilisation (sulcular incision) (very low certainty).

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Oral health-related attitude of nursing staff · Nursing home nursing staff (approximately 95% female in the two contributing studies)

Educational intervention with information and practical components… showed no clear difference in oral health-related attitude of nursing staff compared with (Optimised) usual care; GRADE not reported.

1 finding from 1 review

Experimental chewing adjuncts (bite wafers or chewing gum) vs No chewing gum, placebo, or control (no adjunct)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adolescents/teenagers undergoing orthodontic treatment

Experimental chewing adjuncts (bite wafers or chewing gum) showed no clear difference in patient‐reported pain intensity or pain relief (VAS, NRS or… compared with no chewing gum, placebo, or control (no adjunct); GRADE not reported.

5 findings from 1 review
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Benzodiazepines (systemic clonazepam 0.5 mg/day) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether benzodiazepines (systemic clonazepam 0.5 mg/day) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

1 finding from 1 review

Motivational interview plus oral health education vs Oral health education

Dental state: No clinically important change in plaque index · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

It is very uncertain whether motivational interview plus oral health education changes dental state: No clinically important change in plaque index compared with oral health education (very low certainty).

1 finding from 1 review

Topical bleomycin vs placebo or no treatment

Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
    up to 3 months
    SoF 5, Safety of the intervention up to 3 months: 'All patients in the bleomycin group developed erythema with erosion by the end of the applications, whereas erythema developed in the placebo group. Discomfort was…
    1 study
    GRADE not reported

Preoperative antibiotics vs placebo

Occurrence of postoperative infection - 4 weeks · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether preoperative antibiotic prophylaxis changes occurrence of postoperative infection - 4 weeks compared with placebo (very low certainty).

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Oral health-related knowledge of nursing staff · Nursing home nursing staff (approximately 95% female in the two contributing studies)

Educational intervention with information and practical components… showed no clear difference in oral health-related knowledge of nursing staff compared with (Optimised) usual care; GRADE not reported.

1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Oral health: Not having seen a dentist in the past year · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) vs Conventional mechanical caries removal (standard drill; handpiece with a bur)

Pulpal inflammation or necrosis · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)

It is very uncertain whether laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) changes pulpal inflammation or necrosis compared with conventional mechanical caries removal (standard drill; handpiece… (very low certainty).

3 findings from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - healed ('healed' vs 'improved', 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - healed ('healed' vs 'improved',… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
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