Intervention not reported
Outcome№ of participants(studies)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
ACQ responders at 6 months ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of participants: 3700(3 RCTs)
The intervention showed no clear difference in ACQ responders at 6 months ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of… (moderate certainty).
1 finding from 1 review
Patient discomfort during treatment (anxiety scale) · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars
One study found no significant difference in patient discomfort between SDF and ART (p = 0.15; ungraded).
1 finding from 1 review
Angular cheilitis (WHO clinical stage 2) · Children or adolescents
No significant difference in angular cheilitis prevalence between CLWH and healthy controls (pooled OR 1.95, 95% CI 0.16 to 23.65).
1 finding from 1 review
Dental caries prevalence · European adolescents aged 17 years
Pooled caries prevalence was 0.84.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of LACC1 (chr13q14.11) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted LACC1 expression reached the TWAS threshold for ECC (p = 3.98e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
Biodentine had a significantly higher pulpotomy success rate than MTA (indirect comparison; numeric estimate not available); ungraded.
1 finding from 1 review
Dental caries prevalence · European adolescents aged 14 years
Pooled caries prevalence was 0.82.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of NRAD1 (LINC00284) (chr13q14.11) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted NRAD1 (LINC00284) expression reached the TWAS threshold for ECC (p = 1.69e-6) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars
SDF was not significantly better than ART at arresting caries (pooled ES 0.05, 95% CI -0.42 to 0.51; ungraded).
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R31 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R31 was suggestively associated with ECC in the TWAS (p = 1.04e-5); genetic association, ungraded.
1 finding from 1 review
Caries experience · European adolescents aged 15 years
Pooled caries experience was 6.62 (I² = 97.6%).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis and open (immature) root apex due to carious pulp exposure
In open-apex teeth, pooled pulpotomy success was 95.8% (95% CI 81-99%); significantly higher than closed apex (z=2.33, p=0.02); ungraded.
1 finding from 1 review
Oral candidiasis (WHO clinical stage 3) · Children or adolescents
CLWH on ART had markedly higher prevalence of oral candidiasis than healthy controls (pooled OR 16.94, 95% CI 5.06 to 56.70).
1 finding from 1 review
Choking · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
No systematic reviews or studies assessed choking risk for RCF or NRCF (only BLW/BLISS); this is an evidence gap.
1 finding from 1 review
Dental caries · Children and adolescents (general population, aged under 20 years)
Across two studies, 50% showed any association of potential public health harm for dental caries (very low certainty).
1 finding from 1 review
Choking · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
No significant difference in choking risk was found between BLW/BLISS-fed and traditionally fed infants (ungraded).
1 finding from 1 review
Body weight / BMI · Children and adolescents (general population, aged under 20 years)
Evidence on food marketing and body weight is very uncertain (very low certainty); a single study found no association.
1 finding from 1 review
Beta diversity and community composition · Participants in oral 16S rRNA caries microbiome studies
Beta-diversity matrices showed statistically significant ADONIS results, while clustering by study and 16S region was also observed; no pooled effect estimate was reported.
1 finding from 1 review
Lightness/brightness change of white spot lesion (luminosity L*, T0 to T1) · Patients with post-orthodontic white spot lesions and permanent dentition
ICON resin infiltration showed no statistically significant change in lightness/brightness of post-orthodontic white spot lesions at 6 months (pooled Cohen's d/SMD -0.001, 95% CI -0.23 to 0.23; 3 studies, 330 teeth; I2=97%); not GRADE-rated.
1 finding from 1 review