Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,097 questions · 3,266 findings · 631 reviews

No studies found 430 · 13.2%GRADE not reported 193 · 5.9%Very low 995 · 30.5%Low 904 · 27.7%Moderate 591 · 18.1%High 153 · 4.7%

ICS + LAMA add‐on vs ICS dose increase

Mean exacerbations requiring a course of oral corticosteroids · adults with asthma

ICS + LAMA add‐on showed no clear difference in exacerbations requiring a course of OCSa 14 weeks compared with ICS dose increase (low certainty).

1 finding from 1 review

Intervention not reported

Incidence of pulmonary tuberculosis in children with HIV infection ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of pulmonary tuberculosis in children with HIV infection ‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of Pneumocystis carinii pneumonia infection in children with cancer ‐ trimethoprim‐sulfamethoxazole prophylaxis only · children with cancers aged 12 years and under

The intervention probably leads to lower incidence of Pneumocystis carinii pneumonia infection in children… (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention probably leads to lower mortality in children with HIV infection ‐ co‐trimoxazole… (moderate certainty).

1 finding from 1 review