Cochrane · systematic review · CD011437
Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults with asthma
Evans, DJW, Kew, KM, Anderson, DE, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 85.7%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ICS + LAMA add‐on compared to ICS dose increase for adults with asthma
Population: adults with asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations requiring a course of OCSa 14 weeks ICS + LAMA add‐on vs ICS dose increase | OR 0.57 [0.22, 1.43] | 1 study · 174 participants | Low Downgraded: imprecision, indirectness |
AQLQ score (Scale 1 to 7, where 1 = severely impaired and 7 = no impairment) ICS + LAMA add‐on vs ICS dose increase | no estimate extracted | 1 study · 1 participants | Low Downgraded: indirectness |
SAEs (all cause) ICS + LAMA add‐on vs ICS dose increase | OR 1 [0.2, 5.09] | 1 study · 174 participants | Low Downgraded: imprecision, indirectness |
Exacerbations requiring hospitalisation 14 weeks ICS + LAMA add‐on vs ICS dose increase | OR 1 [0.06, 16.24] | 1 study · 174 participants | Low Downgraded: imprecision, indirectness |
Exacerbations requiring ED visit 14 weeks ICS + LAMA add‐on vs ICS dose increase | OR 0.49 [0.09, 2.77] | 1 study · 174 participants | Low Downgraded: imprecision, indirectness |
FEV1 pre‐albuterol (L) ICS + LAMA add‐on vs ICS dose increase | no estimate extracted | 1 study · 1 participants | Moderate Downgraded: indirectness |
ACQ score Scale = 0 to 6 (0 = no impairment; 6 = maximum impairment) ICS + LAMA add‐on vs ICS dose increase | no estimate extracted | 1 study · 1 participants | Low Downgraded: indirectness |