What do systematic reviews say?

Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 1% with chlorhexidine 2% final rinse vs Sodium hypochlorite 1% with normal saline final rinse

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  Only a graph plot of 'average pain' over the 7-day postoperative period in each group was provided; this could not be transformed into usable data for the review's prespecified outcomes.
  1 study
  GRADE not reported

Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

LongoVital (herbal component alone) vs placebo

LongoVital (herbal component alone) showed no clear difference in number of days of ulcers (monthly average) compared with placebo; GRADE not reported.

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  4 to 6 months
  MD -0.80 [-3.30, 1.70]
  1 study · 50 participants
  GRADE not reported

LongoVital (herbal component alone) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  4 months
  Kolseth 2005 (high risk of bias): 40 patients randomised to the herbal component of LongoVital alone or placebo; data presented as medians with 95% CIs, unsuitable for further analysis; no statistically significant…
  1 study · 40 participants
  GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  Follow-up at 3, 6 and 12 weeks
  Table 5, mean (SD) intakes/day at main meals: intervention 2.8 (0.5) baseline, 0.7 (0.7) at 3 weeks, 0.8 (0.9) at 6 weeks, 2.3 (0.8) at 12 weeks; control 1.9 (1.1), 1.9 (1.2), 1.9 (1.1), 2.0 (0.9). Significant…
  1 study · 20 participants
  GRADE not reported

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Individually designed, patient-centred preventive programme: dietary… led to higher using xylitol products more than 3 times per day compared with basic prevention offered as standard in public dental clinics; GRADE not reported.

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  2 to 4 years
  RR 1.32 [1.04, 1.68]
  1 study · 497 participants
  GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  Follow-up at 3, 6 and 12 weeks
  Table 5, total mean (SD) intakes/day: intervention 9.5 (1.9) baseline, 1.6 (1.4) at 3 weeks, 1.8 (1.5) at 6 weeks, 7.8 (3.5) at 12 weeks; control 7.2 (2.6), 7.1 (3.7), 6.5 (4.2), 6.7 (2.2). Significant reduction versus…
  1 study · 20 participants
  GRADE not reported

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Chlorhexidine, 0.2% to 2% (solution or gel)

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 5.25% vs Normal saline

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3%

Sodium hypochlorite 5.25% showed no clear difference in proportion of participants with moderate to severe pain 72 hours to… compared with sodium hypochlorite 5.25% with hydrogen peroxide 3%; GRADE not reported.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  RR 1.22 [0.4, 4.2]
  1 study · 167 participants
  GRADE not reported

Breastfeeding (post cleft-lip surgery) vs Spoon-feeding

• Feeding interventions for growth and development in infants with cleft lip, cleft palate or cleft lip and palate 2011 · Cochrane All outcomes

  post-surgery
  Duration of hospital stay (days): no statistically significant difference between the two groups (Darzi 1996); no pooled estimate displayed (totals not selected).
  1 study · 40 participants
  GRADE not reported

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to lower length of hospital stay (days) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

• Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
  MD -1.40 [-1.92, -0.88]
  1 study · 21 participants
  GRADE not reported

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher number of participants discharged on the same day as surgery compared with traditional iliac crest cancellous bone graft; GRADE not reported.

• Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
  RR 20
  1 study · 21 participants
  GRADE not reported

Intranasal steroid spray vs control

• Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
  no estimate extracted
  200 participants
  Moderate

Epinephrine vs steroids

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with steroid (moderate certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 1.08 [0.77, 1.52]
  1 study · 399 participants
  Moderate

Epinephrine vs placebo

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with placebo (low certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 0.81 [0.63, 1.03]
  3 studies · 875 participants
  Low

Epinephrine vs salbutamol/albuterol

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with salbutamol/albuterol (moderate certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 1.05 [0.71, 1.54]
  2 studies · 212 participants
  Moderate

Epinephrine and steroid vs placebo

Epinephrine and steroid may leads to lower admissions overall up to 7 days (outpatients only) compared with placebo (low certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 0.64 [0.44, 0.95]
  1 study · 400 participants
  Low