Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,429 questions · 3,558 findings · 436 reviews

No studies found 660 · 18.5%GRADE not reported 375 · 10.5%Very low 727 · 20.4%Low 887 · 24.9%Moderate 709 · 19.9%High 200 · 5.6%

IPL (with/without MGX) vs no treatment/sham

Dry eye symptoms, measured using the OSDI score (ranging from 0 to 100 units, with a reduction in scores indicating clinical improvement) at 1‐month (with actual · people with meibomian gland dysfunction

It is very uncertain whether IPL (with/without MGX) changes dry eye symptoms, measured using the SPEED score at 3 months of compared with sham or no treatment (with/without MGX) (very low certainty).

1 finding from 1 review

IPL (with/without MGX) vs no treatment/sham

Tear osmolarity, measured in mOsmol/L, at 3 months of · people with meibomian gland dysfunction

IPL (with/without MGX) showed no clear difference in tear osmolarity, measured in mOsmol/L, at 3 months of compared with sham or no treatment (with/without MGX) (low certainty).

1 finding from 1 review

IPL (with/without MGX) vs no treatment/sham

Meibomian gland orifice plugging, at 3 months of · people with meibomian gland dysfunction

It is very uncertain whether IPL (with/without MGX) changes meibomian gland orifice plugging, at 3 months of compared with sham or no treatment (with/without MGX) (very low certainty).

1 finding from 1 review

IPL (with/without MGX) vs no treatment/sham

Corneal sodium fluorescein staining, measured using a validated clinical scale, at 3 months of · people with meibomian gland dysfunction

It is very uncertain whether IPL (with/without MGX) changes corneal sodium fluorescein staining, measured using a validated… compared with sham or no treatment (with/without MGX) (very low certainty).

1 finding from 1 review

Oxygen‐guided lung‐recruitment maneuver vs usual care

Death at hospital discharge · preterm infants < 37 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome

Oxygen‐guided lung‐recruitment maneuver showed no clear difference in mortality by hospital discharge compared with routine care (low certainty).

1 finding from 1 review