Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

418 questions · 611 findings · 68 reviews

No studies found 88 · 14.4%GRADE not reported 237 · 38.8%Very low 74 · 12.1%Low 115 · 18.8%Moderate 87 · 14.2%High 10 · 1.6%

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Presence of osteopenia · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted or adjustable individualized fortification changes osteopenia compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

External uterine compression (all methods) plus normal care vs normal care

Mortality due to bleeding ‐ not reported · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

The review found no eligible studies for this question.

1 finding from 1 review

External uterine compression (all methods) plus normal care vs normal care

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) ‐ not reported · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

The review found no eligible studies for this question.

1 finding from 1 review

Bakri balloon tamponade vs condom‐loaded Foley Catheter (one intrauterine tamponade compared to another intrauterine tamponade technique)

Hysterectomy to control bleeding · women with primary atonic postpartum haemorrhage following vaginal delivery

It is very uncertain whether bakri balloon tamponade changes hysterectomy to control bleeding compared with condom‐loaded Foley Catheter (one intrauterine tamponade compared to… (very low certainty).

1 finding from 1 review

Bakri balloon tamponade vs condom‐loaded Foley Catheter (one intrauterine tamponade compared to another intrauterine tamponade technique)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women with primary atonic postpartum haemorrhage following vaginal delivery

The review found no eligible studies for this question.

1 finding from 1 review

Bakri balloon tamponade vs condom‐loaded Foley Catheter (one intrauterine tamponade compared to another intrauterine tamponade technique)

Number of women with total blood loss 1000 mL or more after randomisation · women with primary atonic postpartum haemorrhage following vaginal delivery

The review found no eligible studies for this question.

1 finding from 1 review

Bakri balloon tamponade vs condom‐loaded Foley Catheter (one intrauterine tamponade compared to another intrauterine tamponade technique)

Mean blood loss (mL) (trialist defined) · women with primary atonic postpartum haemorrhage following vaginal delivery

The review found no eligible studies for this question.

1 finding from 1 review

Bakri balloon tamponade vs condom‐loaded Foley Catheter (one intrauterine tamponade compared to another intrauterine tamponade technique)

Blood transfusion (red cell or whole blood) · women with primary atonic postpartum haemorrhage following vaginal delivery

It is very uncertain whether bakri balloon tamponade changes blood transfusion (red cell or whole blood) compared with condom‐loaded Foley Catheter (one intrauterine tamponade compared to… (very low certainty).

1 finding from 1 review

Bakri balloon tamponade vs condom‐loaded Foley Catheter (one intrauterine tamponade compared to another intrauterine tamponade technique)

Side effects of the intervention (e.g. trauma, necrosis) · women with primary atonic postpartum haemorrhage following vaginal delivery

The review found no eligible studies for this question.

1 finding from 1 review

External uterine compression (all methods) plus normal care vs normal care

Blood transfusion (red cell or whole blood) · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

It is very uncertain whether external uterine compression (all methods) plus normal care changes blood transfusion (red cell or whole blood) compared with normal care (very low certainty).

1 finding from 1 review

External uterine compression (all methods) plus normal care vs normal care

Side effects of the intervention (e.g. trauma, necrosis) ‐ not reported · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

The review found no eligible studies for this question.

1 finding from 1 review

Higher‐dose vs lower‐dose nicotine patch

Smoking cessation · people who smoke

Higher‐dose showed no clear difference in smoking cessation ‐ 42/44 mg versus 21/22 mg (24‐hour patches) compared with lower‐dose nicotine patch (moderate certainty).

3 findings from 1 review