Findings

What do systematic reviews say?

873 questions · 883 findings · 38 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 319 · 36.1%GRADE not reported 18 · 2%Very low 198 · 22.4%Low 186 · 21.1%Moderate 147 · 16.6%High 15 · 1.7%

Laser therapy vs no laser therapy

Change in visual loss associated with PSR: visual loss is defined by the deterioration of visual acuity of 3 lines or more with the Snellen chart · children and adults with SCD and PSR

1 finding from 1 review

Laser therapy for retinopathy in sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 414 participants
Very low

Laser therapy vs no laser therapy

Occurence of vitreous haemorrhage · children and adults with SCD and PSR

1 finding from 1 review

Laser therapy for retinopathy in sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 414 participants
Low

Laser therapy vs no laser therapy

Adverse effects · children and adults with SCD and PSR

1 finding from 1 review

Laser therapy for retinopathy in sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 414 participants
Low

Summary of findings: oral β‐carotene vs placebo

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Very low

Summary of findings: oral β‐carotene vs placebo

Quality of life · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: oral β‐carotene vs placebo

Change in BMI · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: oral β‐carotene vs placebo

Time to next exacerbation · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: oral β‐carotene vs placebo

Adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Very low

Summary of findings ‐ Exercise alone vs exercise plus electrophysical modality

Adverse events · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Exercise alone vs exercise plus electrophysical modality

Quality of life · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Exercise alone vs exercise plus electrophysical modality

Pain · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Exercise alone vs exercise plus electrophysical modality

Functional ability · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Exercise alone vs exercise plus electrophysical modality

Joint health: Modified Colorado Score · participants with haemophilia

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 25 participants
Very low

Bisphosphonates vs placebo or no treatment

BMD Z score (total hip/femoral neck) · adults with β‐thalassaemia and osteoporosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bisphosphonates vs placebo or no treatment

BMD Z score (lumbar spine) · adults with β‐thalassaemia and osteoporosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bisphosphonates vs placebo or no treatment

BMD Z score (wrist) · adults with β‐thalassaemia and osteoporosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bisphosphonates vs placebo or no treatment

Incidence of fractures · adults with β‐thalassaemia and osteoporosis

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 118 participants
Moderate

Bisphosphonates vs placebo or no treatment

Mobility · adults with β‐thalassaemia and osteoporosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bisphosphonates vs placebo or no treatment

Quality of life (change in mean back pain) · adults with β‐thalassaemia and osteoporosis

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 118 participants
Very low

Bisphosphonates vs placebo or no treatment

Adverse effects of treatment · adults with β‐thalassaemia and osteoporosis

It is very uncertain whether summary of findings – bisphosphonates changes adverse effects of treatment compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
OR 15
2 studies · 143 participants
Very low