FEV1 · adults with asthma
1 finding from 1 review
no estimate extracted
1 study · 1 participants
Moderate
ACQ score Scale = 0 to 6 (0 = no impairment; 6 = maximum impairment) · adults with asthma
1 finding from 1 review
no estimate extracted
1 study · 1 participants
Low
Number of participants with exacerbations requiring systemic steroids · patients with chronic asthma
LABA + ICS leads to lower participants with one or more exacerbations requiring systemic… compared with LTRA + ICS (high certainty).
1 finding from 1 review
Change from baseline in morning PEFR (L/min) Duration of trials: 8 to 13 weeks · patients with chronic asthma
1 finding from 1 review
Lung function: FEV1 mL (change from baseline) · patients with chronic asthma
1 finding from 1 review
Rescue‐free days: % change from baseline · patients with chronic asthma
1 finding from 1 review
Use of rescue medication · patients with chronic asthma
1 finding from 1 review
Withdrawals due to any reason · patients with chronic asthma
LABA + ICS probably leads to lower withdrawals for any reason compared with LTRA + ICS (moderate certainty).
1 finding from 1 review
Serious adverse events · patients with chronic asthma
LABA + ICS showed no clear difference in serious adverse events compared with LTRA + ICS (moderate certainty).
1 finding from 1 review
Intervention not reported
SGRQ Scores range from 0 to 100, with higher scores indicating more limitations · 18 to 80 years of age with bronchiectasis
The intervention showed no clear difference in SGRQ Scores range from 0 to 100, with higher scores indicating more… (low certainty).
1 finding from 1 review
Intervention not reported
TDI Total scores range from ‐ 9 to +9. The lower the score, the greater the deterioration in severity of dyspnoea, MCID ≥ 1 · 18 to 80 years of age with bronchiectasis
The intervention may leads to higher TDI Total scores range from ‐ 9 to +9. The lower the score, the… (low certainty).
1 finding from 1 review
Intervention not reported
Cough‐free days Percentage of days free of cough · 18 to 80 years of age with bronchiectasis
The intervention may leads to higher cough‐free days Percentage of days free of cough (low certainty).
1 finding from 1 review
Intervention not reported
Hospitalisations, number of participants with 1 or more exacerbations · 18 to 80 years of age with bronchiectasis
The intervention showed no clear difference in hospitalisations, number of participants with 1 or more exacerbations (low certainty).
1 finding from 1 review
Annual Exacerbation Rates · COPD
Combined inhalers probably leads to lower annual exacerbation rates compared with placebo (primary outcomes) (moderate certainty).
1 finding from 1 review
Adverse events—'serious'—320/94 Duration of 10 months3 · COPD
Budesonide/formoterol (BDF) showed no clear difference in adverse events—'serious'—320/94 Duration of 10 months3 compared with placebo (low certainty).
1 finding from 1 review
OR 1.17 [0.95, 1.45]
2476 participants
Low
Adverse events—'serious'—160/94 Duration of nine months 3 · COPD
Budesonide/formoterol (BDF) showed no clear difference in adverse events—'serious'—160/94 Duration of nine months 3 compared with placebo (low certainty).
1 finding from 1 review
OR 1.2 [0.89, 1.63]
1556 participants
Low
Adverse events at study endpoint · patients with chronic obstructive pulmonary disease
Mometasone/formoterol (MF/F) showed no clear difference in adverse event—any—400/103 Duration of six months compared with placebo (low certainty).
2 findings from 1 review
OR 0.98 [0.75, 1.3]
890 participants
Low
OR 0.82 [0.62, 1.09]
894 participants
Low
Adverse events—serious—400/103 Duration of six months · patients with chronic obstructive pulmonary disease
Mometasone/formoterol (MF/F) showed no clear difference in adverse events—serious—400/103 Duration of six months compared with placebo (low certainty).
1 finding from 1 review
OR 1.09 [0.66, 1.79]
890 participants
Low
Adverse events—serious—200/103 Duration of six months · patients with chronic obstructive pulmonary disease
Mometasone/formoterol (MF/F) showed no clear difference in adverse events—serious—200/103 Duration of six months compared with placebo (low certainty).
1 finding from 1 review
OR 0.71 [0.41, 1.23]
894 participants
Low
Exacerbations (number of people experiencing ≥ 1 exacerbations) · COPD
Combined inhalers probably leads to lower participants with at least one exacerbation Duration of six months3 compared with placebo (primary outcomes) (moderate certainty).
1 finding from 1 review
OR 0.78 [0.66, 0.93]
3141 participants
Moderate