Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,327 questions · 2,494 findings · 87 reviews · All outcomes

No studies found 450 · 18%GRADE not reported 1,487 · 59.6%Very low 385 · 15.4%Low 121 · 4.9%Moderate 50 · 2%High 1 · 0%

Locking plate vs 2 mm non-locking titanium plates

Restoration of function (functional occlusion; bite force as surrogate) · Adults (16 to 68 years) with mandibular fractures excluding condylar involvement
1 finding from 1 review
  • Functional occlusion was achieved in all participants in both intervention groups (Agarwal 2011); the measurement of this outcome was not clearly reported. Bite force was reported as a surrogate/proxy outcome.
    1 study
    GRADE not reported

Colchicine (0.5 mg three times per day) vs Clofazimine (100 mg daily for 30 days, then 100 mg every other day)

Complete remission, pain intensity, patient and physician evaluation · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • One trial at high risk of bias (de Abreu 2009) compared clofazimine (n=23) with colchicine (n=23). The number with no further aphthous episodes at 6 months was significantly greater in the clofazimine group than the…
    1 study · 46 participants
    GRADE not reported

Colchicine (0.5 mg three times per day) vs Clofazimine (100 mg daily for 30 days, then 100 mg every other day)

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • Clofazimine was associated with an increase in cutaneous adverse effects (Fisher's exact test P=0.015), easily controlled; there was a greater percentage of treatment interruptions in the colchicine group due to…
    1 study · 46 participants
    GRADE not reported

OASIS moisturising mouthwash vs Experimental mouthwash formulation

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Shirodaria 2006 (crossover): OASIS reported to give a statistically significant improvement over subjects' normal remedies, but the report did not present the randomised OASIS-versus-experimental comparison; no data…
    1 study
    GRADE not reported

Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash vs Chlorhexidine mouthwash

Patient satisfaction (desire for future use) · Adults with dental implants and healthy peri-implant soft tissues at baseline

Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash led to higher patient satisfaction (desire for future use) compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Severe pain for > 1 week · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… led to higher severe pain for > 1 week compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Brushing vs no treatment

Total anaerobes (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Brushing led to lower total anaerobes (colony forming units, log-transformed) compared with no treatment; GRADE not reported.

1 finding from 1 review

Effervescent tablets vs no treatment

Fusobacteria (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Effervescent tablets led to lower fusobacteria (colony forming units, log-transformed) compared with no treatment; GRADE not reported.

1 finding from 1 review

Brushing vs no treatment

Fusobacteria (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Brushing led to lower fusobacteria (colony forming units, log-transformed) compared with no treatment; GRADE not reported.

1 finding from 1 review

Brushing vs Effervescent tablets

Fusobacteria (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Brushing led to higher fusobacteria (colony forming units, log-transformed) compared with effervescent tablets; GRADE not reported.

1 finding from 1 review

Effervescent tablets vs Association of brushing and effervescent tablets

Total anaerobes (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Effervescent tablets showed no clear difference in total anaerobes (colony forming units, log-transformed) compared with association of brushing and effervescent tablets; GRADE not reported.

1 finding from 1 review

Effervescent tablets vs no treatment

Total anaerobes (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Effervescent tablets led to lower total anaerobes (colony forming units, log-transformed) compared with no treatment; GRADE not reported.

1 finding from 1 review

Brushing vs Effervescent tablets

Total anaerobes (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Brushing led to higher total anaerobes (colony forming units, log-transformed) compared with effervescent tablets; GRADE not reported.

1 finding from 1 review

Effervescent tablets vs Association of brushing and effervescent tablets

Fusobacteria (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Effervescent tablets showed no clear difference in fusobacteria (colony forming units, log-transformed) compared with association of brushing and effervescent tablets; GRADE not reported.

1 finding from 1 review