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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

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No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Restricted vs standard fluid management

Incidence of hypoglycemia (blood glucose < 40 mg/dL) at end of intervention period (proportions) · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of hypoglycemia (blood glucose < 40 mg/dL) at end of… compared with standard fluid management (very low certainty).

1 finding from 1 review

Restricted vs standard fluid management

Incidence of endotracheal ventilation (proportions) during hospital stay (for infants on no support or noninvasive support at the time of study entry) · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of endotracheal ventilation (proportions) during hospital… compared with standard fluid management (very low certainty).

1 finding from 1 review

Restricted vs standard fluid management

Incidence of noninvasive (nasal CPAP or nasal ventilation) respiratory support during hospital stay · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of noninvasive (nasal CPAP or nasal ventilation)… compared with standard fluid management (very low certainty).

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

All‐cause mortality · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

It is very uncertain whether band ligation changes all‐cause mortality compared with sham or no intervention (very low certainty).

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

Serious adverse events Idiopathic thrombocytopaenic purpura · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

It is very uncertain whether band ligation changes serious adverse events Idiopathic thrombocytopaenic purpura compared with sham or no intervention (very low certainty).

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

Health‐related quality of life · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

The review found no eligible studies for this question.

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

Oesophageal variceal bleeding · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

It is very uncertain whether band ligation changes oesophageal variceal bleeding compared with sham or no intervention (very low certainty).

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

Adverse events considered non‐serious · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Reulceration · people with healed venous leg ulcers

The intervention showed no clear difference in reulceration (low certainty).

1 finding from 1 review

Intervention not reported

Duration of reulceration episodes · people with healed venous leg ulcers
1 finding from 1 review

Intervention not reported

Ulceration on the contralateral leg · people with healed venous leg ulcers
1 finding from 1 review

Intervention not reported

Noncompliance · people with healed venous leg ulcers

The intervention showed no clear difference in noncompliance (low certainty).

1 finding from 1 review

Summary of findings table ‐ Protein vs standard diet

Gastrointestinal adverse events · patients (> 65 years) following hip fracture; patients with a recent stroke

It is very uncertain whether summary of findings table ‐ Protein changes side effects: at least one adverse gastrointestinal event compared with standard diet (very low certainty).

1 finding from 1 review