Findings

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Intervention not reported

Duration of neonatal intensive care unit stay (hours or days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Anaemia · general population of all age groups (including pregnant women) from any country, over two years of age

iron‐fortified wheat flour with or without other micronutrients added may leads to lower anaemia (defined as haemoglobin below WHO cut‐off for age and… compared with wheat flour (no added iron) with the same other micronutrients added (low certainty).

1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Diarrhoea (three liquid stools in a single day) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Respiratory infections (as measured by trialists) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

All‐cause death (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Infection or inflammation at individual level (as measured by urinary neopterin, C‐reactive protein or alpha‐1‐acid glycoprotein variant A) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Iron deficiency (as defined by study authors, based on a biomarker of iron status) · general population of all age groups (including pregnant women) from any country, over two years of age

It is very uncertain whether iron‐fortified wheat flour with or without other micronutrients added changes iron deficiency (as defined by study authors, based on a biomarker… compared with wheat flour (no added iron) with the same other micronutrients added (very low certainty).

1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Diarrhoea (three liquid stools in a single day) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Respiratory infections (as measured by trialists) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

All‐cause death (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Infection or inflammation at individual level as measured by C‐reactive protein (CRP) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Anaemia · general population of all age groups (including pregnant women) from any country, over two years of age

It is very uncertain whether iron‐fortified wheat flour with other micronutrients added changes anaemia (defined as haemoglobin below WHO cut‐off for age and… compared with unfortified wheat flour (no micronutrients added) (very low certainty).

1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Iron deficiency (as defined by study authors, based on a biomarker of iron status) · general population of all age groups (including pregnant women) from any country, over two years of age

Iron‐fortified wheat flour with other micronutrients added probably leads to lower iron deficiency (as defined by study authors, based on a biomarker… compared with unfortified wheat flour (no micronutrients added) (moderate certainty).

1 finding from 1 review

Restricted vs standard fluid management

Incidence of hypernatremia (serum sodium > 145 mEq/L) at end of intervention period (proportions) · late preterm and full‐term infants with transient tachypnea of the newborn

It is very uncertain whether restricted changes incidence of hypernatremia (serum sodium > 145 mEq/L) at end of… compared with standard fluid management (very low certainty).

1 finding from 1 review