Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,747 questions · 3,943 findings · 594 reviews

No studies found 784 · 19.9%GRADE not reported 530 · 13.4%Very low 1,040 · 26.4%Low 981 · 24.9%Moderate 444 · 11.3%High 164 · 4.2%

Active NRT vs placebo ‐ rs2036527 ‐ non‐Hispanic black or African American

End of treatment ‐ homozygous major · people who smoke

Active NRT showed no clear difference in end of treatment ‐ homozygous major compared with placebo ‐ rs2036527 ‐ non‐Hispanic black or African American (low certainty).

1 finding from 1 review

Active NRT vs placebo ‐ rs2036527 ‐ non‐Hispanic black or African American

End of treatment ‐ heterozygous or homozygous minor · people who smoke

Active NRT showed no clear difference in end of treatment ‐ heterozygous or homozygous minor compared with placebo ‐ rs2036527 ‐ non‐Hispanic black or African American (moderate certainty).

1 finding from 1 review

Intervention not reported

PIPP score intra procedure Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · neonates with pain associated with orogastric tube insertion
1 finding from 1 review

Intervention not reported

PIPP score 30 seconds post procedure Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · neonates with pain associated with orogastric tube insertion
1 finding from 1 review

Intervention not reported

PIPP score 1 min post procedure Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · neonates with pain associated with orogastric tube insertion
1 finding from 1 review

Complete cure for ketoconazole vs griseofulvin

Proportion of participants with complete cure · children infected with Trichophyton

Complete cure for ketoconazole showed no clear difference in proportion of participants with complete cure compared with griseofulvin (low certainty).

2 findings from 1 review

Psychological therapies vs tricyclic antidepressants (TCAs)

Short‐term improvement Scale used (range; lower is better): Clinical Global Impression (1 to 7) Agoraphobic Cognitions Questionnaire (1 to 70) Panic Disorder Severity Scale (0 to 28) Brief Scale for Anxiety (0 to 60) · adults with panic disorder
1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Secondary outcome: acceptability of treatment · depression in adults

It is very uncertain whether S‐adenosyl methionine as monotherapy changes acceptability Participants dropping out of treatment during the… compared with tricyclic antidepressant agent (very low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

> 50% reduction in depressive symptoms · depression in adults

It is very uncertain whether S‐adenosyl methionine as monotherapy changes proportions of participants responding to treatment ≥ 50% reduction… compared with tricyclic antidepressant agent (very low certainty).

1 finding from 1 review