Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Interferon‐α alone vs standard targeted therapies

QoL · previously untreated patients with mRCC
5 findings from 1 review
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Targeted immunotherapy alone vs standard targeted therapies

Quality of life: improved to an important degree · previously treated patients with mRCC

Targeted immunotherapy alone probably leads to higher quality of life: Clinically relevant improvement in FKSI‐DRS compared with standard targeted therapies (moderate certainty).

2 findings from 1 review

Targeted mass media intervention vs general population mass media intervention

Attempts to quit smoking · mass media intervention for promoting healthy behaviours

It is very uncertain whether targeted mass media intervention changes quit‐attempts, 3 months compared with general population mass media intervention (very low certainty).

1 finding from 1 review