Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,126 questions · 1,225 findings · 111 reviews

No studies found 235 · 19.2%GRADE not reported 260 · 21.2%Very low 207 · 16.9%Low 271 · 22.1%Moderate 177 · 14.4%High 75 · 6.1%

Vitamin D vs placebo

Rate of exacerbations requiring systemic corticosteroids · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more exacerbations treated… compared with placebo (high certainty).

1 finding from 1 review

Vitamin D vs placebo

Patients with severe exacerbations (requiring hospitalisation or ER visit) · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more exacerbations requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo

Proportion of participants with one or more serious adverse events due to any cause · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more serious adverse events… compared with placebo (high certainty).

1 finding from 1 review

Vitamin D vs placebo

Withdrawals (parallel group trials/first arm cross‐over trials) · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in withdrawals from trial compared with placebo (high certainty).

1 finding from 1 review