Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

508 questions · 529 findings · 58 reviews

No studies found 191 · 36.1%GRADE not reported 49 · 9.3%Very low 143 · 27%Low 92 · 17.4%Moderate 51 · 9.6%High 3 · 0.6%

Heparin vs normal saline solution locking

CVC‐related bloodstream infections (positive microbiological culture, participant as unit of analysis) · adults with CVCs

It is very uncertain whether heparin changes CVC‐related bloodstream infections (positive microbiological… compared with normal saline solution locking (very low certainty).

1 finding from 1 review

Hydrogel dressings vs saline gauze

Complete wound healing · people with venous leg ulcers

It is very uncertain whether hydrogel dressings changes complete wound healing compared with gauze and saline (very low certainty).

1 finding from 1 review

Any intervention vs artificial tears or saline

Proportion of participants in whose eyes SEIs had developed within 30 days of treatment initiation (lower is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants in whose eyes SEIs had developed within… compared with artificial tears or saline (very low certainty).

1 finding from 1 review

Any intervention vs artificial tears or saline

Proportion of participants in whose eyes SEI had disappeared within 21 days of treatment (higher is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants in whose eyes SEI had disappeared within… compared with artificial tears or saline (very low certainty).

1 finding from 1 review

Dornase alfa vs hypertonic saline

FEV1 · children with cystic fibrosis

Dornase alfa may leads to higher mean relative percentage in FEV1 (L) at 3 months compared with hypertonic saline (low certainty).

1 finding from 1 review