Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

309 questions · 325 findings · 45 reviews · Acute Respiratory Infections

No studies found 38 · 11.7%GRADE not reported 31 · 9.5%Very low 54 · 16.6%Low 78 · 24%Moderate 106 · 32.6%High 18 · 5.5%

Semi‐recumbent position (30º to 60º) vs supine

Duration of ICU stay · adults requiring mechanical ventilation

Semi‐recumbent position (30º to 60º) showed no clear difference in length of ICU stay compared with supine position (0° to 10°) (moderate certainty).

1 finding from 1 review

Semi‐recumbent position (30º to 60º) vs supine

Length of hospital stay · adults requiring mechanical ventilation

It is very uncertain whether semi‐recumbent position (30º to 60º) changes length of hospital stay compared with supine position (0° to 10°) (very low certainty).

1 finding from 1 review

Semi‐recumbent positioning: 45° vs 25° to 30°

Microbiologically confirmed VAP · adults requiring mechanical ventilation

It is very uncertain whether semi‐recumbent positioning: 45° changes microbiologically confirmed VAP compared with 25° to 30° (very low certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Rubella cases Initial meta‐analysis ‐ clinical diagnosis or serology +/‐ virus isolation +/‐ clinical signs · susceptible people exposed to rubella

Gamma‐globulin probably leads to lower rubella cases Initial meta‐analysis ‐ clinical diagnosis or serology… compared with control (saline or no treatment) (moderate certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Subgroup: rubella cases Estimated dose 0.027 to 0.037 ml/lb11 Clinical diagnosis by 2 physicians · susceptible people exposed to rubella

Gamma‐globulin showed no clear difference in subgroup: rubella cases Estimated dose 0.027 to 0.037 ml/lb11… compared with control (saline or no treatment) (low certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Subgroup: rubella cases Estimated dose 0.1 to 0.15 ml/lb11 Serology +/‐ virus isolation +/‐ clinical signs · susceptible people exposed to rubella

Gamma‐globulin leads to lower subgroup: rubella cases Estimated dose 0.1 to 0.15 ml/lb11 Serology… compared with control (saline or no treatment) (high certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Subgroup: rubella cases Estimated dose 0.2 to 0.5 ml/lb11 Serology +/‐ virus isolation +/‐ clinical signs · susceptible people exposed to rubella

Gamma‐globulin showed no clear difference in subgroup: rubella cases Estimated dose 0.2 to 0.5 ml/lb11 Serology… compared with control (saline or no treatment) (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of pulmonary tuberculosis in children with HIV infection ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of pulmonary tuberculosis in children with HIV infection ‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of Pneumocystis carinii pneumonia infection in children with cancer ‐ trimethoprim‐sulfamethoxazole prophylaxis only · children with cancers aged 12 years and under

The intervention probably leads to lower incidence of Pneumocystis carinii pneumonia infection in children… (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention probably leads to lower mortality in children with HIV infection ‐ co‐trimoxazole… (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in mortality in children with HIV infection ‐ isoniazid prophylaxis only (low certainty).

1 finding from 1 review