Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Exacerbation frequency · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Adverse effects of treatment · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

Oral plus nebulised antibiotics showed no clear difference in adverse effects of treatment compared with oral antibiotics plus nebulised placebo (low certainty).

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Eradication of MRSA · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

Oral plus nebulised antibiotics showed no clear difference in eradication of MRSA compared with oral antibiotics plus nebulised placebo (low certainty).

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Time until next positive MRSA isolate (from clinically relevant respiratory culture) · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous iron with oral iron vs oral iron

Persistent anaemia symptoms Reported by the women · women with postpartum iron deficiency anaemia

It is very uncertain whether intravenous iron with oral iron changes persistent anaemia symptoms ‐ 1 week Visual Analogue Scale ≥ 7 compared with oral iron (Comparison 6) (very low certainty).

3 findings from 1 review

Oral antibiotics vs placebo

Measurements of eradication or decrease in numbers of colonies of positive cultures of bacteria · adult participants with chronic blepharitis

The review found no eligible studies for this question.

1 finding from 1 review