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What do systematic reviews say?

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Evidence found and GRADE certainty

1,411 questions · 1,474 findings · 170 reviews

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No studies found 336 · 22.8%GRADE not reported 97 · 6.6%Very low 419 · 28.4%Low 395 · 26.8%Moderate 188 · 12.8%High 39 · 2.6%

Intervention not reported

Self‐reported injuries or medically‐attended injuries · cyclists

The review found no eligible studies for this question.

1 finding from 1 review

Anticonvulsant vs placebo

Adverse events ‐ Withdrawn for medical reasons · patients with alcohol dependence

Anticonvulsants showed no clear difference in adverse events—withdrawn for medical reasons compared with placebo (moderate certainty).

1 finding from 1 review

Eculizumab vs placebo

Adverse events (serious and nonserious) Medical Dictionary for Regulatory Activities (MedDRA) · patients with paroxysmal nocturnal hemoglobinuria

Eculizumab showed no clear difference in adverse events (serious and nonserious) Medical Dictionary for… compared with placebo (low certainty).

1 finding from 1 review

Parenting interventions vs usual care

Medically attended or self‐reported injuries ‐ RCTs only · parents of children between the ages of 0 and 18 years

Parenting interventions probably leads to lower medically attended or self‐reported injuries ‐ RCTs only compared with usual care (moderate certainty).

1 finding from 1 review

Summary of findings: multimedia education and a co‐intervention vs co‐intervention alone

Health outcome (Number who had a medical complication of pelvic inflammatory disease) · patients taking prescribed and over‐the‐counter medications or their carers

Summary of findings: multimedia education and a co‐intervention showed no clear difference in health outcome (Number who had a medical complication of pelvic… compared with co‐intervention alone (low certainty).

1 finding from 1 review

Intervention not reported

Greatest crash reductions in areas within 2km of camera sites, with 31% (1100), 39% (2200), 19% (500) and 21% (1600) reductions estimated for hospitalisation, medically treated, other injury and non‐injury crashes respectively.
1 finding from 1 review

Antidepressants vs placebo

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ Withdrawn for medical reasons: Tricyclics versus placebo · patients with depression during opioid agonist treatment for opioid dependence

The intervention leads to higher adverse events ‐ Withdrawn for medical reasons: Tricyclics versus… (high certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ Withdrawn for medical reasons: SSRI versus placebo · patients with depression during opioid agonist treatment for opioid dependence

The intervention showed no clear difference in adverse events ‐ Withdrawn for medical reasons: SSRI versus placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo according to any definition (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Adverse event nausea and vomiting (0 to 24 hours) · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in gastrointestinal side effects (nausea and/or vomiting) compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Complete abortion rate · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in complete abortion rate compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Unscheduled contact with care · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in unscheduled contact with care compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review