Stroke · prevention of SCI in people with SCD and normal TCD velocities
Long‐term RBC transfusion showed no clear difference in clinical stroke compared with standard care (low certainty).
1 finding from 1 review
Cognitive function · prevention of SCI in people with SCD and normal TCD velocities
1 finding from 1 review
Quality of life · prevention of SCI in people with SCD and normal TCD velocities
1 finding from 1 review
Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and abnormal TCD velocities
Long‐term RBC transfusion may leads to lower proportion of participants developing new or progressive SCI lesions compared with standard care (low certainty).
1 finding from 1 review
All‐cause mortality · prevention of SCI in people with SCD and abnormal TCD velocities
1 finding from 1 review
Self‐reported pain relief ‐ NPSI: ranges from 0 to 100. Higher scores are indicative of neuropathic pain. · adults and children with sickle cell disease experiencing neuropathic pain
1 finding from 1 review
Self‐reported pain relief ‐ S‐LANSS: Possible total scores range from 0 to 24, and a score of 12 or higher is indicative of neuropathic pain. · adults and children with sickle cell disease experiencing neuropathic pain
1 finding from 1 review
Patient Global Impression of Change · adults and children with sickle cell disease experiencing neuropathic pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Time to improvement of symptoms · adults and children with sickle cell disease experiencing neuropathic pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
QoL · adults and children with sickle cell disease experiencing neuropathic pain
1 finding from 1 review
Quality of sleep · adults and children with sickle cell disease experiencing neuropathic pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Treatment‐related adverse effects · adults and children with sickle cell disease experiencing neuropathic pain
It is very uncertain whether summary of findings ‐ Pharmacological intervention (pregabalin) changes treatment‐related adverse effects compared with placebo (very low certainty).
1 finding from 1 review
Intervention not reported
SCD knowledge:children Pre‐ and post‐knowledge assessment Duration of · patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Healthcare utilization clinic visits, emergency room visits and hospital admissions Duration of · patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Positive coping Coping attempts and coping strategies Duration of · patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Depression standardised depression scores · patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Patient‐reported signs and symptoms/ self‐management · patients with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
SCD knowledge: caregiver Pre‐ and post‐knowledge assessment Duration of · caregivers of patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Family relationship Pre‐intervention and post‐intervention assessment Home visits and training session for family members Patient‐caregiver relationships assessed pre‐intervention and immediately post‐intervention. · caregivers of patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Caregiver‐reported signs and symptoms Lead to self management · caregivers of patients with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found