Findings

What do systematic reviews say?

3,234 questions · 3,357 findings · 396 reviews

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No studies found 803 · 23.9%GRADE not reported 270 · 8%Very low 757 · 22.5%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Intervention not reported

True negativespeople without amikacin resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis‐positive by Xpert MTB/XDR Index test: Xpert…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 425 participants
High

Intervention not reported

False positivespeople incorrectly classified as having amikacin resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis‐positive by Xpert MTB/XDR Index test: Xpert…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 425 participants
High

Intervention not reported

False negativespeople incorrectly classified as not having pulmonary tuberculosis · people with presumptive pulmonary tuberculosisRole: an initial testIndex test: Xpert MTB/XDRThreshold for index test: an automated result…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 799 participants
Very low

Intervention not reported

True negativespeople without pulmonary tuberculosis · people with presumptive pulmonary tuberculosisRole: an initial testIndex test: Xpert MTB/XDRThreshold for index test: an automated result…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 429 participants
Very low

Intervention not reported

False positivespeople incorrectly classified as having pulmonary tuberculosis · people with presumptive pulmonary tuberculosisRole: an initial testIndex test: Xpert MTB/XDRThreshold for index test: an automated result…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 429 participants
Very low

Intervention not reported

Test result · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

The review found no eligible studies for this question.

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

True positivespeople with isoniazid resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 756 participants
Moderate

Intervention not reported

False negativespeople incorrectly classified as not having isoniazid resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 756 participants
Moderate

Intervention not reported

True negativespeople without isoniazid resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 327 participants
Moderate

Paracetamol (single administration, any dose) vs placebo

Adequate pain relief as reported by women · women with perineal pain following childbirth

Paracetamol (single administration, any dose) may leads to higher adequate pain relief as reported by women compared with placebo (low certainty).

1 finding from 1 review

Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
RR 2.14 [1.59, 2.89]
10 studies · 1279 participants
Low

Paracetamol (single administration, any dose) vs placebo

Additional pain relief · women with perineal pain following childbirth

Paracetamol (single administration, any dose) may leads to lower additional pain relief compared with placebo (low certainty).

1 finding from 1 review

Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
RR 0.34 [0.21, 0.55]
8 studies · 1132 participants
Low

Paracetamol (single administration, any dose) vs placebo

Nausea · women with perineal pain following childbirth

Paracetamol (single administration, any dose) showed no clear difference in maternal drug adverse effects (nausea) compared with placebo (low certainty).

1 finding from 1 review

Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
RR 0.18 [0.01, 3.66]
1 study · 232 participants
Low

Paracetamol (single administration, any dose) vs placebo

Maternal drug adverse effects (sleepiness) · women with perineal pain following childbirth

Paracetamol (single administration, any dose) showed no clear difference in maternal drug adverse effects (sleepiness) compared with placebo (low certainty).

1 finding from 1 review

Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
RR 0.89 [0.18, 4.3]
1 study · 232 participants
Low

Paracetamol (single administration, any dose) vs placebo

Neonatal drug adverse effects · women with perineal pain following childbirth

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Recombinant human thyrotropin‐aided radioiodine vs radioiodine

Health‐related quality of life

1 finding from 1 review

Recombinant human thyrotropin (rhTSH)‐aided radioiodine treatment for non‐toxic multinodular goitre 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 85 participants
Very low

Recombinant human thyrotropin‐aided radioiodine vs radioiodine

Hypothyroidism

Recombinant human thyrotropin‐aided radioiodine probably leads to higher hypothyroidism compared with radioiodine (moderate certainty).

1 finding from 1 review

Recombinant human thyrotropin (rhTSH)‐aided radioiodine treatment for non‐toxic multinodular goitre 2021 · Cochrane Headline outcomes only
RR 2.53 [1.52, 4.2]
6 studies · 321 participants
Moderate

Recombinant human thyrotropin‐aided radioiodine vs radioiodine

Adverse events

Recombinant human thyrotropin‐aided radioiodine showed no clear difference in adverse events compared with radioiodine (low certainty).

1 finding from 1 review

Recombinant human thyrotropin (rhTSH)‐aided radioiodine treatment for non‐toxic multinodular goitre 2021 · Cochrane Headline outcomes only
RR 1.24 [0.94, 1.63]
6 studies · 321 participants
Low

Recombinant human thyrotropin‐aided radioiodine vs radioiodine

Thyroid volume

1 finding from 1 review

Recombinant human thyrotropin (rhTSH)‐aided radioiodine treatment for non‐toxic multinodular goitre 2021 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 268 participants
Moderate

Recombinant human thyrotropin‐aided radioiodine vs radioiodine

All‐cause mortality

1 finding from 1 review

Recombinant human thyrotropin (rhTSH)‐aided radioiodine treatment for non‐toxic multinodular goitre 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Very low

Recombinant human thyrotropin‐aided radioiodine vs radioiodine

Costs

The review found no eligible studies for this question.

1 finding from 1 review

Recombinant human thyrotropin (rhTSH)‐aided radioiodine treatment for non‐toxic multinodular goitre 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found