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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

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No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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High‐dose vs low‐dose colchicine

Total adverse events · acute gout

High‐dose may leads to higher total adverse events compared with low‐dose colchicine (low certainty).

1 finding from 1 review

Paracetamol (single administration, any dose) vs placebo

Adequate pain relief as reported by women · women with perineal pain following childbirth

Paracetamol (single administration, any dose) may leads to higher adequate pain relief as reported by women compared with placebo (low certainty).

1 finding from 1 review

Paracetamol (single administration, any dose) vs placebo

Maternal drug adverse effects (sleepiness) · women with perineal pain following childbirth

Paracetamol (single administration, any dose) showed no clear difference in maternal drug adverse effects (sleepiness) compared with placebo (low certainty).

1 finding from 1 review

MDA vs no MDA

Parasitaemia prevalence · People of all ages living in an area with very low to low endemicity of P falciparum malaria ( < 10% prevalence)

It is very uncertain whether MDA changes parasitaemia prevalence compared with no MDA (very low certainty).

6 findings from 1 review
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MDA vs no MDA

Parasitaemia prevalence · People of all ages living in an area with very low to low endemicity of P vivax malaria (< 10% prevalence)

MDA may leads to lower parasitaemia prevalence compared with no MDA (low certainty).

6 findings from 1 review
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MDA vs no MDA

Confirmed malaria illness incidence · People of all ages living in an area with very low to low endemicity of P vivax malaria (< 10% prevalence)

It is very uncertain whether MDA changes confirmed malaria illness incidence compared with no MDA (very low certainty).

1 finding from 1 review

MDA vs no MDA

Parasitaemia incidence · People of all ages living in an area with very low to low endemicity of P falciparum malaria ( < 10% prevalence)

MDA probably leads to lower parasitaemia incidence compared with no MDA (moderate certainty).

1 finding from 1 review

MDA vs no MDA

Confirmed malaria illness incidence · People of all ages living in an area with very low to low endemicity of P falciparum malaria ( < 10% prevalence)

It is very uncertain whether MDA changes confirmed malaria illness incidence compared with no MDA (very low certainty).

2 findings from 1 review

Drain use vs No drain

All‐cause mortality · people undergoing elective pancreatic resections

Drain use showed no clear difference in mortality compared with no drain use following pancreatic surgery (low certainty).

2 findings from 1 review

Active drain vs passive drain

Intra‐abdominal infection · people undergoing elective pancreatic resections

It is very uncertain whether active drain changes intra‐abdominal infection compared with passive drain following pancreatic surgery (very low certainty).

1 finding from 1 review