Cochrane · systematic review · CD008846
Mass drug administration for malaria
Shah, MP, Hwang, J, Choi, L, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
19
current version
GRADE rated
19
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 11 · 57.9%Low 6 · 31.6%Moderate 2 · 10.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
MDA compared to no MDA for Plasmodium falciparum malaria (moderate to high endemicity, short‐term follow‐up)
Population: People of all ages living in an area with moderate to high endemicity of P falciparum malaria (≥ 10% prevalence)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitaemia prevalence MDA vs no MDA | RR 1.76 [0.58, 5.36] | 1 study · 786 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasitaemia incidence MDA vs no MDA | Rate ratio 0.61 [0.4, 0.92] | 1 study · 739 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Confirmed malaria illness incidence MDA vs no MDA | Rate ratio 0.41 [0.04, 4.42] | 1 study · 144422 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
MDA compared to no MDA for Plasmodium falciparum malaria (very low to low endemicity, short‐term follow‐up)
Population: People of all ages living in an area with very low to low endemicity of P falciparum malaria (< 10% prevalence)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitaemia prevalence MDA vs no MDA | RR 0.12 [0.03, 0.52] | 1 study · 1232 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasitaemia prevalence MDA vs no MDA | RR 0.25 [0.15, 0.41] | 7 studies · 17454 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Parasitaemia incidence MDA vs no MDA | Rate ratio 0.37 [0.21, 0.66] | 1 study · 736 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Confirmed malaria illness incidence MDA vs no MDA | Rate ratio 0.58 [0.12, 2.73] | 2 studies · 130651 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
MDA compared to no MDA for Plasmodium falciparum malaria (very low to low endemicity, long‐term follow‐up)
Population: People of all ages living in an area with very low to low endemicity of P falciparum malaria ( < 10% prevalence)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitaemia prevalence MDA vs no MDA | RR 0.82 [0.2, 3.34] | 1 study · 1537 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Confirmed malaria illness incidence MDA vs no MDA | Rate ratio 0.77 [0.2, 3.03] | 1 study · 23251 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasitaemia prevalence MDA vs no MDA | RR 0.34 [0.06, 1.97] | 1 study · 1393 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasitaemia prevalence MDA vs no MDA | RR 0.89 [0.22, 3.62] | 1 study · 1521 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasitaemia prevalence MDA vs no MDA | RR 1.25 [0.25, 6.31] | 1 study · 1679 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
MDA compared to no MDA for P vivax malaria (very low to low endemicity, short‐term follow‐up)
Population: People of all ages living in an area with very low to low endemicity of P vivax malaria (< 10% prevalence)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitaemia prevalence MDA vs no MDA | RR 0.18 [0.08, 0.4] | 1 study · 1232 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasitaemia prevalence MDA vs no MDA | RR 0.15 [0.1, 0.24] | 5 studies · 6896 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Confirmed malaria illness incidence MDA vs no MDA | Rate ratio 1.38 [0.97, 1.95] | 2 studies · 3325 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
MDA compared to no MDA for P vivax malaria (very low to low endemicity, long‐term follow‐up)
Population: People of all ages living in an area with very low to low endemicity of P vivax malaria (< 10% prevalence)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitaemia prevalence MDA vs no MDA | RR 0.81 [0.44, 1.48] | 1 study · 1537 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasitaemia prevalence MDA vs no MDA | RR 0.84 [0.38, 1.83] | 1 study · 1393 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasitaemia prevalence MDA vs no MDA | RR 0.89 [0.41, 1.94] | 1 study · 1521 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasitaemia prevalence MDA vs no MDA | RR 1.2 [0.44, 3.29] | 1 study · 1679 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |