Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in mortality from all causes up to 30 days from study entry compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Number of participants with WHO grade 3 or 4 bleeding up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in number of participants with WHO grade 3 or 4 bleeding up to 30 days… compared with high‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in mortality from all causes up to 30 days from study entry compared with high‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Number of participants with at least 1 clinically significant bleeding event up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in number of participants with at least 1 clinically significant… compared with high‐dose schedule (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

HIV incidence (observational studies) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HIV incidence (person/years) compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

HIV prevalence · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HIV prevalence compared with standard care (low certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Herpes Simplex Virus 2 (HSV‐2) incidence (person/years) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in herpes Simplex Virus 2 (HSV‐2) incidence (person/years) compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

HSV‐2 prevalence · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HSV‐2 prevalence compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Two or more sexual partners in last year · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in two or more sexual partners in last year compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Use of birth control methods (condom use at last sex) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use probably leads to higher use of condom during last sexual intercourse compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Knowledge: condom can prevent STIs · low and high‐risk populations

Structural and community‐level interventions for increasing condom use probably leads to higher knowledge: condom can prevent STIs compared with standard care (moderate certainty).

1 finding from 1 review