Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,410 questions · 8,901 findings · 1,091 reviews

No studies found 1,687 · 19%GRADE not reported 1,469 · 16.5%Very low 1,969 · 22.1%Low 2,060 · 23.1%Moderate 1,302 · 14.6%High 414 · 4.7%

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High‐dose vs low‐dose colchicine

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

High‐dose showed no clear difference in participant global assessment of treatment success: proportion with… compared with low‐dose colchicine (low certainty).

1 finding from 1 review

High‐dose vs low‐dose colchicine

Total adverse events · acute gout

High‐dose may leads to higher total adverse events compared with low‐dose colchicine (low certainty).

1 finding from 1 review

Paracetamol (single administration, any dose) vs placebo

Adequate pain relief as reported by women · women with perineal pain following childbirth

Paracetamol (single administration, any dose) may leads to higher adequate pain relief as reported by women compared with placebo (low certainty).

1 finding from 1 review

Paracetamol (single administration, any dose) vs placebo

Maternal drug adverse effects (sleepiness) · women with perineal pain following childbirth

Paracetamol (single administration, any dose) showed no clear difference in maternal drug adverse effects (sleepiness) compared with placebo (low certainty).

1 finding from 1 review

MDA vs no MDA

Parasitaemia prevalence · People of all ages living in an area with very low to low endemicity of P falciparum malaria ( < 10% prevalence)

It is very uncertain whether MDA changes parasitaemia prevalence compared with no MDA (very low certainty).

6 findings from 1 review
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MDA vs no MDA

Parasitaemia prevalence · People of all ages living in an area with very low to low endemicity of P vivax malaria (< 10% prevalence)

MDA may leads to lower parasitaemia prevalence compared with no MDA (low certainty).

6 findings from 1 review
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MDA vs no MDA

Confirmed malaria illness incidence · People of all ages living in an area with very low to low endemicity of P vivax malaria (< 10% prevalence)

It is very uncertain whether MDA changes confirmed malaria illness incidence compared with no MDA (very low certainty).

1 finding from 1 review

MDA vs no MDA

Parasitaemia incidence · People of all ages living in an area with very low to low endemicity of P falciparum malaria ( < 10% prevalence)

MDA probably leads to lower parasitaemia incidence compared with no MDA (moderate certainty).

1 finding from 1 review

MDA vs no MDA

Confirmed malaria illness incidence · People of all ages living in an area with very low to low endemicity of P falciparum malaria ( < 10% prevalence)

It is very uncertain whether MDA changes confirmed malaria illness incidence compared with no MDA (very low certainty).

2 findings from 1 review