Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

OHSS · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts showed no clear difference in ovarian hyperstimulation syndrome rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Clinical pregnancy rate · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts leads to higher clinical pregnancy rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Miscarriage · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts showed no clear difference in miscarriage rate per pregnancy compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Multiple pregnancy rate · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts showed no clear difference in multiple pregnancy rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Complete resolution of endophthalmitis at 3 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

It is very uncertain whether combined steroid and antibiotic therapy changes complete resolution of endophthalmitis at 3 months' compared with antibiotics alone (very low certainty).

1 finding from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Visual acuity · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy may leads to higher visual acuity 6/6 to 6/18 at 3 months' compared with antibiotics alone (low certainty).

2 findings from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Adverse events at 3 to 12 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy showed no clear difference in adverse events at 3 to 12 months' compared with antibiotics alone (low certainty).

1 finding from 1 review

Higher‐dose anticoagulants vs lower‐dose anticoagulants

Necessity for additional respiratory support · people hospitalised with COVID‐19

It is very uncertain whether higher‐dose anticoagulants changes necessity for additional respiratory support compared with lower‐dose anticoagulants (very low certainty).

1 finding from 1 review

Systemic corticosteroids plus intranasal steroid/mucolytic/decongestant vs no intervention

Psychophysical testing for recovery of sense of smell · adults with olfactory dysfunction for ≥ 4 weeks following COVID‐19 infection

It is very uncertain whether systemic corticosteroids plus intranasal… changes psychophysical testing for recovery of sense of smell compared with no intervention (very low certainty).

1 finding from 1 review