Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

NSAIDs vs placebo

Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with fibromyalgia

It is very uncertain whether NSAID changes substantial pain relief: at least 50% reduction in pain, or PGIC… compared with placebo (very low certainty).

1 finding from 1 review

NSAIDs vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with fibromyalgia

It is very uncertain whether NSAID changes moderate pain relief: at least 30% reduction in pain, or PGIC much… compared with placebo (very low certainty).

1 finding from 1 review