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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,751 questions in 147 reviews · Pain, Palliative and Supportive Care
current versionsNo studies 361 · 20.6%Ungraded 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pregabalin 300 mg vs placebo Dizziness · adults with moderate or severe pain associated with postherpetic neuralgia Pregabalin for neuropathic pain in adults (2019) · Cochrane | no estimate extracted | 5 studies · 933 participants | Moderate |
Pregabalin 300 mg vs placebo Adverse event withdrawal · adults with moderate or severe pain associated with postherpetic neuralgia Pregabalin for neuropathic pain in adults (2019) · Cochrane | no estimate extracted | 5 studies · 933 participants | High |
Pregabalin 600 mg vs placebo At least 30% pain intensity reduction · adults with moderate or severe pain associated with postherpetic neuralgia Pregabalin for neuropathic pain in adults (2019) · Cochrane | no estimate extracted | 3 studies · 537 participants | Moderate |
Pregabalin 600 mg vs placebo At least 50% pain intensity reduction · adults with moderate or severe pain associated with postherpetic neuralgia Pregabalin for neuropathic pain in adults (2019) · Cochrane | no estimate extracted | 4 studies · 732 participants | Moderate |
Intervention NR Parenting behaviors, post‐treatment Higher scores indicate greater maladaptive parenting behavior · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 9 studies · 1040 participants | Low |
Intervention NR Child mental health symptoms, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 10 studies · 1244 participants | Moderate |
Intervention NR Child medical symptoms, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 10 studies · 1136 participants | Low |
Intervention NR Family functioning, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 3 studies · 201 participants | Very low |
Intervention NR Parenting behaviors, post‐treatment Higher scores indicate greater maladaptive parenting behavior · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 7 studies · 947 participants | Low |
Intervention NR Parent mental health symptoms, post‐treatment Higher scores indicate greater mental health symptoms · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 6 studies · 891 participants | Moderate |
Intervention NR Child behavior/disability, post‐treatment Higher scores indicate greater disability · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 3 studies · 247 participants | Very low |
Intervention NR Child mental health symptoms, post‐treatment Higher scores indicate greater mental health symptoms · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 4 studies · 276 participants | Very low |
Intervention NR Child medical symptoms, post‐treatment Higher scores indicate greater medical symptoms · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 5 studies · 679 participants | Very low |
Intervention NR Family functioning, post‐treatment Higher scores indicate poorer family functioning · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 2 studies · 237 participants | Very low |
Intervention NR Parenting behaviors, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 6 studies · 852 participants | Very low |
Intervention NR Parent mental health symptoms, post‐treatment Higher scores indicate greater mental health symptoms · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 8 studies · 811 participants | Very low |
Intervention NR Parent mental health symptoms, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 5 studies · 800 participants | Moderate |
Intervention NR Child behavior/disability, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 2 studies · 114 participants | Very low |
Intervention NR Child mental health symptoms, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 3 studies · 212 participants | Very low |
Intervention NR Child medical symptoms, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 3 studies · 210 participants | Very low |
Intervention NR Family functioning, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 1 study · 101 participants | Very low |
Intervention NR Child behavior/disability, post‐treatment Higher scores indicate greater disability · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 10 studies · 1236 participants | Moderate |
Intervention NR Child mental health symptoms, post‐treatment Higher scores indicate greater mental health symptoms · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 15 studies · 1786 participants | High |
Intervention NR Child medical symptoms, post‐treatment Higher scores indicate greater medical symptoms · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 13 studies · 1434 participants | Very low |
Intervention NR Family functioning, post‐treatment Higher scores indicate poorer family functioning · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 5 studies · 429 participants | Very low |
Intervention NR Parenting behaviors, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 6 studies · 743 participants | Moderate |
Intervention NR Parent mental health symptoms, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 5 studies · 592 participants | Very low |
Intervention NR Child behavior/disability, · parents of children with chronic illness Psychological interventions for parents of children and adolescents with chronic illness (2019) · Cochrane | no estimate extracted | 8 studies · 1038 participants | Moderate |
Herbal treatment vs placebo Participant‐reported pain relief of 30% or greater Immediately post‐intervention · adults with neuropathic pain Herbal medicinal products or preparations for neuropathic pain (2019) · Cochrane | RR 1.12 [0.69, 1.85] | 1 study · 74 participants | Very low |
Herbal treatment vs placebo Participant‐reported pain relief of 50% or greater Immediately post‐intervention · adults with neuropathic pain Herbal medicinal products or preparations for neuropathic pain (2019) · Cochrane | no estimate extracted | NR | No studies |
Herbal treatment vs placebo Participant‐reported global impression of clinical change (PGIC) much or very much improved (moderate) Immediately post‐intervention · adults with neuropathic pain Herbal medicinal products or preparations for neuropathic pain (2019) · Cochrane | no estimate extracted | NR | No studies |
Herbal treatment vs placebo Participant‐reported global impression of clinical change (PGIC) very much improved (substantial) Immediately post‐intervention · adults with neuropathic pain Herbal medicinal products or preparations for neuropathic pain (2019) · Cochrane | no estimate extracted | NR | No studies |
Herbal treatment vs placebo Any pain‐related outcome indicating some improvement VAS 1‐100 Immediately post‐intervention (high score indicates more pain relief) · adults with neuropathic pain Herbal medicinal products or preparations for neuropathic pain (2019) · Cochrane | no estimate extracted | 1 study · 74 participants | Very low |
Herbal treatment vs placebo Study withdrawals Post‐intervention · adults with neuropathic pain Herbal medicinal products or preparations for neuropathic pain (2019) · Cochrane | RR 0.83 [0.26, 2.64] | 2 studies · 128 participants | Very low |
Herbal treatment vs placebo Adverse events Post‐intervention · adults with neuropathic pain Herbal medicinal products or preparations for neuropathic pain (2019) · Cochrane | RR 1 [0.55, 1.81] | 2 studies · 128 participants | Very low |
Intervention NR Achievement of at least 50% reduction in headache severity Post‐treatment Higher scores indicate more children with reduced headache · children or adolescents with headaches Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | RR 2.02 [1.35, 3.01] | 7 studies · 379 participants | Very low |
Intervention NR Disability Post‐treatment Lower scores indicate lower levels of disability · children or adolescents with mixed chronic pain conditions Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 3 studies · 363 participants | Very low |
Intervention NR Disability · children or adolescents with mixed chronic pain conditions Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 1 study · 269 participants | Very low |
Intervention NR Depression Post‐treatment Lower scores indicate lower levels of depression · children or adolescents with mixed chronic pain conditions Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 2 studies · 317 participants | Very low |
Intervention NR Anxiety Post‐treatment Lower scores indicate lower levels of anxiety · children or adolescents with mixed chronic pain conditions Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 2 studies · 370 participants | Very low |
Intervention NR Anxiety · children or adolescents with mixed chronic pain conditions Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 1 study · 269 participants | Very low |
Intervention NR Achievement of at least 50% reduction in headache severity · children or adolescents with headaches Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | RR 1.76 [0.88, 3.52] | 4 studies · 230 participants | Very low |
Intervention NR Disability Post‐treatment Lower scores indicate lower levels of disability · children or adolescents with headaches Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 5 studies · 440 participants | Very low |
Intervention NR Disability · children or adolescents with headaches Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 3 studies · 341 participants | Very low |
Intervention NR Depression Post‐treatment Lower scores indicate lower levels of depression · children or adolescents with headaches Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 4 studies · 422 participants | Very low |
Intervention NR Anxiety Post‐treatment Lower scores indicate lower levels of anxiety · children or adolescents with headaches Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 3 studies · 380 participants | Very low |
Intervention NR Anxiety · children or adolescents with headaches Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 3 studies · 360 participants | Very low |
Intervention NR Pain intensity Post‐treatment Lower scores indicate lower levels of pain intensity · children or adolescents with mixed chronic pain conditions Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 5 studies · 501 participants | Very low |
Intervention NR Pain intensity · children or adolescents with mixed chronic pain conditions Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children… (2019) · Cochrane | no estimate extracted | 2 studies · 301 participants | Very low |
Non‐steroidal anti‐inflammatory drugs (NSAID) vs placebo Participant‐reported pain relief of 50% or greater · adults with sickle cell disease in a vaso‐occlusive crises Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults (2019) · Cochrane | no estimate extracted | NR | No studies |