Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,938 questions · 1,994 findings · 246 reviews · Headline outcomes only

No studies found 490 · 24.6%GRADE not reported 71 · 3.6%Very low 669 · 33.6%Low 446 · 22.4%Moderate 264 · 13.2%High 54 · 2.7%

Combined trabeculotomy with trabeculectomy vs trabeculotomy

Proportion of participants with IOP≤ 21 mmHg, with or without ocular hypotensive medications 1 year · children at or before five years of age with primary congenital glaucoma

It is very uncertain whether combined trabeculotomy with trabeculectomy changes surgical success: proportion with postoperative IOP ≤ 21 mmHg with… compared with trabeculotomy (very low certainty).

1 finding from 1 review

Viscotrabeculotomy vs conventional trabeculotomy

Proportion with postoperative IOP ≤ 21 mmHg (surgical success) with or without glaucoma medications 6 months after surgery · children at or before five years of age with primary congenital glaucoma

It is very uncertain whether viscotrabeculotomy changes proportion with postoperative IOP ≤ 21 mmHg (surgical success) with… compared with conventional trabeculotomy (very low certainty).

1 finding from 1 review

Microcatheter‐assisted trabeculotomy vs conventional trabeculotomy

Proportion of participants with IOP≤ 21 mmHg, with or without ocular hypotensive medications 1 year · children at or before five years of age with primary congenital glaucoma

Microcatheter‐assisted trabeculotomy probably leads to higher proportion with postoperative IOP ≤ 21 mmHg (surgical success) with… compared with conventional trabeculotomy (moderate certainty).

1 finding from 1 review

Intervention not reported

Surgical site infection (all wound classifications) Inspection of the wound1 ( · Patients undergoing surgery

The intervention leads to higher surgical site infection (all wound classifications) Inspection of… (high certainty).

1 finding from 1 review

Intervention not reported

Surgical site infection Inspection of the wound1 ( · Patients undergoing surgery

The intervention showed no clear difference in surgical site infection Inspection of the wound1 ( (moderate certainty).

1 finding from 1 review

Intramedullary fixation vs open reduction and internal fixation with plate

Treatment failure (participants who have a non‐routine secondary surgical intervention) ‐ Overall treatment failure · adults (aged ≥ 16 years) with acute middle third clavicle fractures

It is very uncertain whether intramedullary fixation changes treatment failure (participants who have a non‐routine secondary… compared with open reduction and internal fixation with plate (very low certainty).

1 finding from 1 review

Surgical abortion procedures: mid‐level providers vs doctors

Failure/incomplete abortion (observational studies) Provider or supervisor assessment · Patients requesting abortion procedures

It is very uncertain whether surgical abortion procedures: mid‐level providers changes failure/incomplete abortion (observational studies) Provider or… compared with doctors (very low certainty).

1 finding from 1 review