Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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HFNC vs nasal intermittent positive pressure ventilation

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

It is very uncertain whether nasal high flow changes death (before hospital discharge) or BPD (supplemental… compared with nasal intermittent positive pressure ventilation (very low certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

All‐cause mortality · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume showed no clear difference in mortality compared with high tidal volume (low certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Pneumonia · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower pneumonia compared with high tidal volume (moderate certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Need for postoperative non‐invasive ventilatory support · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower need for postoperative non‐invasive ventilatory support compared with high tidal volume (moderate certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Need for postoperative invasive ventilatory support · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower need for postoperative invasive ventilatory support compared with high tidal volume (moderate certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Barotrauma (pneumothorax) · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

It is very uncertain whether low tidal volume changes barotrauma: pneumothorax compared with high tidal volume (very low certainty).

1 finding from 1 review