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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

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No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

Oral long‐chain omega‐3 PUFAs vs placebo or no treatment

Change in tear osmolarity (measured in mOsmol/L, with reductions in osmolarity indicating clinical improvement) at 1‐month (with actual · people with dry eyea

Oral long‐chain omega‐3 PUFAs (ie, EPA and DHA) showed no clear difference in change in tear osmolarity (measured in mOsmol/L, with reductions in… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Any Psychosocial intervention plus pharm vs psychosocial interventions

Harmful alcohol use · alcohol use disorder
2 findings from 1 review

Any Psychosocial intervention plus pharm vs psychosocial interventions

Retention [ · alcohol use disorder

Pharmacologic intervention along with psychosocial intervention showed no clear difference in retention compared with psychosocial intervention alone (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term oral antiplatelet therapy vs avoiding antithrombotic therapy

MACE · survivors of stroke due to intracerebral haemorrhage

Summary of findings table ‐ Starting long‐term oral antiplatelet… showed no clear difference in MACE compared with avoiding antithrombotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term oral antiplatelet therapy vs avoiding antithrombotic therapy

Death · survivors of stroke due to intracerebral haemorrhage

Summary of findings table ‐ Starting long‐term oral antiplatelet… showed no clear difference in death compared with avoiding antithrombotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term oral antiplatelet therapy vs avoiding antithrombotic therapy

All major occlusive vascular events · survivors of stroke due to intracerebral haemorrhage

Summary of findings table ‐ Starting long‐term oral antiplatelet… showed no clear difference in all major occlusive vascular events compared with avoiding antithrombotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term oral antiplatelet therapy vs avoiding antithrombotic therapy

Intracerebral haemorrhage (ICH) · survivors of stroke due to intracerebral haemorrhage

Summary of findings table ‐ Starting long‐term oral antiplatelet… showed no clear difference in intracerebral haemorrhage (ICH) compared with avoiding antithrombotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term oral antiplatelet therapy vs avoiding antithrombotic therapy

Functional outcomes · survivors of stroke due to intracerebral haemorrhage

Summary of findings table ‐ Starting long‐term oral antiplatelet… showed no clear difference in fnctional status (mRS 0‐2) compared with avoiding antithrombotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term therapeutic dose oral anticoagulation vs avoiding anticoagulation

Functional ability · survivors of stroke due to intracerebral haemorrhage with atrial fibrillation

Summary of findings table ‐ Starting long‐term therapeutic dose oral… showed no clear difference in functional status (mRS 0‐2) compared with avoiding anticoagulation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term therapeutic dose oral anticoagulation vs avoiding anticoagulation

MACE · survivors of stroke due to intracerebral haemorrhage with atrial fibrillation

Summary of findings table ‐ Starting long‐term therapeutic dose oral… probably leads to lower MACE (MACE) compared with avoiding anticoagulation (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term therapeutic dose oral anticoagulation vs avoiding anticoagulation

Death · survivors of stroke due to intracerebral haemorrhage with atrial fibrillation

Summary of findings table ‐ Starting long‐term therapeutic dose oral… showed no clear difference in death compared with avoiding anticoagulation (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term therapeutic dose oral anticoagulation vs avoiding anticoagulation

All major occlusive vascular events · survivors of stroke due to intracerebral haemorrhage with atrial fibrillation

Summary of findings table ‐ Starting long‐term therapeutic dose oral… probably leads to lower all major occlusive vascular events compared with avoiding anticoagulation (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term therapeutic dose oral anticoagulation vs avoiding anticoagulation

Intracranial haemorrhage · survivors of stroke due to intracerebral haemorrhage with atrial fibrillation

Summary of findings table ‐ Starting long‐term therapeutic dose oral… showed no clear difference in intracranial haemorrhage compared with avoiding anticoagulation (moderate certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Mortality before hospital discharge · term and preterm infants resuscitated at birth, using positive pressure ventilation

Nasal interfaces (single nasal prong, binasal prongs (long or… showed no clear difference in death before discharge compared with face mask (low certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Intubation and mechanical ventilation in the DR · term and preterm infants resuscitated at birth, using positive pressure ventilation

It is very uncertain whether nasal interfaces (single nasal prong, binasal prongs (long or… changes intubation and mechanical ventilation in the DR compared with face mask (very low certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Intubation and mechanical ventilationwithin 24 hours of birth · term and preterm infants resuscitated at birth, using positive pressure ventilation

It is very uncertain whether nasal interfaces (single nasal prong, binasal prongs (long or… changes intubation and mechanical ventilationwithin 24 hours of birth compared with face mask (very low certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Intubation and mechanical ventilation outside the DR during hospitalisation · term and preterm infants resuscitated at birth, using positive pressure ventilation

It is very uncertain whether nasal interfaces (single nasal prong, binasal prongs (long or… changes intubation and mechanical ventilation outside the DR during… compared with face mask (very low certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Air leak (any) · term and preterm infants resuscitated at birth, using positive pressure ventilation

Nasal interfaces (single nasal prong, binasal prongs (long or… showed no clear difference in air leaks compared with face mask (low certainty).

1 finding from 1 review