Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

334 questions · 337 findings · 56 reviews

No studies found 77 · 22.8%GRADE not reported 5 · 1.5%Very low 113 · 33.5%Low 75 · 22.3%Moderate 61 · 18.1%High 6 · 1.8%

Portosystemic shunts vs endoscopic intervention with or without medical treatment

Chronic hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes chronic hepatic encephalopathy compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Total shunt vs endoscopic intervention

All‐cause mortality · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether total shunt changes all‐cause mortality compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Sinonasal debridement vs no debridement

Significant adverse effects: significant bleeding requiring intervention, severe pain, iatrogenic injury · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

The review found no eligible studies for this question.

1 finding from 1 review

Sinonasal debridement vs no debridement

Adhesion rate · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

Sinonasal debridement may leads to lower adhesion rate compared with no debridement (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP pancreatitis · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) may leads to higher post‐ERCP pancreatitis compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

CBD cannulation success with the randomised technique (before the use of rescue techniques) · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in CBD cannulation success with the randomised technique (before the… compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Overall success of cannulation · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in overall cannulation success compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP bleeding · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in post‐ERCP bleeding compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP perforation · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in post‐ERCP perforation compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP cholangitis · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in post‐ERCP cholangitis compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

All‐cause mortality · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in mortality compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Recurrent and persistent bleeding overall rates with or without second‐look endoscopy Rebleeding (persistent or recurrent bleeding) · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower recurrent and persistent bleeding overall rates with or without… compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Surgery rate Number requiring emergency surgery · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower surgery rate Number requiring emergency surgery compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Mortality rate Number of deaths (30‐day mortality or in‐hospital mortality) · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower mortality rate Number of deaths (30‐day mortality or in‐hospital… compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Adverse effects of endoscopy therapy Adverse effects · patients with high‐risk bleeding ulcers

Epinephrine probably leads to higher adverse effects of endoscopy therapy Adverse effects compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review