Findings

What do systematic reviews say?

288 questions · 290 findings · 74 reviews · Headline outcomes only

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No studies found 56 · 19.3%GRADE not reported 21 · 7.2%Very low 61 · 21%Low 62 · 21.4%Moderate 39 · 13.4%High 51 · 17.6%

Intervention not reported

Total cholesterol, mmol/L Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

1 finding from 1 review

Fixed‐dose combination therapy for the prevention of atherosclerotic cardiovascular diseases 2017 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 6565 participants
Low

Intervention not reported

LDL cholesterol, mmol/L Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

1 finding from 1 review

Fixed‐dose combination therapy for the prevention of atherosclerotic cardiovascular diseases 2017 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 7153 participants
Moderate

Intervention not reported

Adherence, variable definitions Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

The intervention probably leads to higher adherence, variable definitions Median (moderate certainty).

1 finding from 1 review

Fixed‐dose combination therapy for the prevention of atherosclerotic cardiovascular diseases 2017 · Cochrane Headline outcomes only
RR 1.44 [1.26, 1.65]
4 studies · 3835 participants
Moderate

Intervention not reported

LDL‐cholesterol atorvastatin 10 mg/d · individuals with normal or abnormal lipid profiles

1 finding from 1 review

Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
no estimate extracted
188 studies · 21941 participants
High

Intervention not reported

LDL‐cholesterol atorvastatin 20 mg/d · individuals with normal or abnormal lipid profiles

1 finding from 1 review

Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
no estimate extracted
80 studies · 9310 participants
High

Intervention not reported

LDL‐cholesterol atorvastatin 40 mg/d · individuals with normal or abnormal lipid profiles

1 finding from 1 review

Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
no estimate extracted
37 studies · 3296 participants
High

Intervention not reported

LDL‐cholesterol atorvastatin 80 mg/d · individuals with normal or abnormal lipid profiles

1 finding from 1 review

Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
no estimate extracted
37 studies · 4281 participants
High

Intervention not reported

WDAEb all doses · individuals with normal or abnormal lipid profiles

1 finding from 1 review

Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
no estimate extracted
34 studies · 3688 participants
Very low

Intervention not reported

LDL‐Cholesterol rosuvastatin 2.5 mg/day · participantswith normal or abnormal lipid profiles

1 finding from 1 review

Rosuvastatin for lowering lipids 2014 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 450 participants
Low

Intervention not reported

LDL‐Cholesterol rosuvastatin 5 mg/day · participantswith normal or abnormal lipid profiles

1 finding from 1 review

Rosuvastatin for lowering lipids 2014 · Cochrane Headline outcomes only
no estimate extracted
25 studies · 2602 participants
High

Intervention not reported

LDL‐Cholesterol rosuvastatin 10 mg/day · participantswith normal or abnormal lipid profiles

1 finding from 1 review

Rosuvastatin for lowering lipids 2014 · Cochrane Headline outcomes only
no estimate extracted
74 studies · 9855 participants
High

Intervention not reported

LDL‐Cholesterol rosuvastatin 20 mg/day · participantswith normal or abnormal lipid profiles

1 finding from 1 review

Rosuvastatin for lowering lipids 2014 · Cochrane Headline outcomes only
no estimate extracted
28 studies · 3675 participants
High

Intervention not reported

LDL‐Cholesterol rosuvastatin 40 mg/day · participantswith normal or abnormal lipid profiles

1 finding from 1 review

Rosuvastatin for lowering lipids 2014 · Cochrane Headline outcomes only
no estimate extracted
18 studies · 3512 participants
High

Intervention not reported

WDAE2 all doses · participantswith normal or abnormal lipid profiles

1 finding from 1 review

Rosuvastatin for lowering lipids 2014 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 1330 participants
Very low

Intervention not reported

Outcomes per woman · couples with an in vitro fertilisation indication

The review found no eligible studies for this question.

1 finding from 1 review

Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Miscarriage · couples with an in vitro fertilisation indication

The intervention showed no clear difference in miscarriage (moderate certainty).

1 finding from 1 review

Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation 2020 · Cochrane Headline outcomes only
OR 1.03 [0.75, 1.41]
10 studies · 1680 participants
Moderate

Intervention not reported

Ongoing pregnancy · couples with an in vitro fertilisation indication

The intervention may leads to lower ongoing pregnancy (low certainty).

1 finding from 1 review

Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation 2020 · Cochrane Headline outcomes only
OR 0.68 [0.51, 0.9]
5 studies · 1121 participants
Low

Intervention not reported

Clinical pregnancy · couples with an in vitro fertilisation indication

The intervention probably leads to lower clinical pregnancy (moderate certainty).

1 finding from 1 review

Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation 2020 · Cochrane Headline outcomes only
OR 0.56 [0.42, 0.73]
5 studies · 1131 participants
Moderate

Intervention not reported

Cumulative live birth · couples with an in vitro fertilisation indication

The intervention showed no clear difference in cumulative live birth (low certainty).

1 finding from 1 review

Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation 2020 · Cochrane Headline outcomes only
OR 1.05 [0.66, 1.66]
1 study · 396 participants
Low

Intervention not reported

Live birth rate after the first embryo transfer · couples with an in vitro fertilisation indication

The intervention showed no clear difference in live birth rate after the first embryo transfer (low certainty).

1 finding from 1 review

Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation 2020 · Cochrane Headline outcomes only
OR 1.1 [0.68, 1.79]
1 study · 396 participants
Low