Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,535 questions · 3,601 findings · 252 reviews · Pregnancy and Childbirth

No studies found 726 · 20.2%GRADE not reported 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal hypothyroidism ‐ pregnancy · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal hypothyroidism ‐ pregnancy compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Low birthweight · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in low birthweight compared with same supplement without iodine or no treatment/placebo (child… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Neonatal hypothyroidism or elevated TSH · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes neonatal hypothyroidism or elevated TSH compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Neonatal adverse effect: elevated TPO‐ab · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes neonatal adverse effect: elevated TPO‐ab compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal hypothyroidism ‐ postpartum · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal hypothyroidism ‐ postpartum compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Preterm birth · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in preterm birth compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal adverse effect: elevated thyroid peroxidase antibodies ‐ pregnancy · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal adverse effect: elevated thyroid peroxidase antibodies ‐… compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review