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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,956 questions in 143 reviews · Musculoskeletal
current versionsNo studies 555 · 28.4%Ungraded 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Surgical intervention vs non‐surgical intervention Quality of life · Adults with symptomatic mild to moderate knee osteoarthritis defined as knee pain and radiographic evidence of non‐end… Surgical interventions for symptomatic mild to moderate knee osteoarthritis (2019) · Cochrane | no estimate extracted | NR | No studies |
Methotrexate vs placebo Disease response · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | RR 1.76 [1.14, 2.7] | 1 study · 221 participants | Low |
Methotrexate vs other DMARDs Health‐related quality of life ‐ not measured · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | NR | No studies |
Methotrexate vs other DMARDs Disease activity ‐ not measured · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | NR | No studies |
Methotrexate vs other DMARDs Radiographic progression ‐ not measured · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | NR | No studies |
Methotrexate vs other DMARDs Serious adverse events (leflunomide) assessed by number of events · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | 2 studies · 61 participants | Very low |
Methotrexate vs other DMARDs Withdrawals due to adverse events (leflunomide) assessed by number of events · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | 2 studies · 61 participants | Very low |
Methotrexate vs other DMARDs Serious adverse events (ciclosporin A) assessed by number of events · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | 1 study · 35 participants | Very low |
Methotrexate vs other DMARDs Withdrawals due to adverse events (ciclosporin A) assessed by number of events · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | RR 1.26 [0.33, 4.82] | 1 study · 35 participants | Very low |
Methotrexate vs placebo Function · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | 1 study · 221 participants | Low |
Methotrexate vs placebo Health‐related quality of life ‐ not reported · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | NR | No studies |
Methotrexate vs placebo Disease activity · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | 1 study · 221 participants | Low |
Methotrexate vs placebo Radiographic progression ‐ not measured · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | NR | No studies |
Methotrexate vs placebo Serious adverse events (SAEs) assessed by number of events · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | RR 0.26 [0.03, 2.26] | 3 studies · 293 participants | Low |
Methotrexate vs placebo Withdrawals due to adverse events (WAEs) assessed by number of events · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | RR 1.32 [0.51, 3.42] | 3 studies · 293 participants | Low |
Methotrexate vs other DMARDs Disease response (leflunomide) · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | RR 1.05 [0.77, 1.45] | 1 study · 30 participants | Very low |
Methotrexate vs other DMARDs Function (leflunomide) · psoriatic arthritis Methotrexate for psoriatic arthritis (2019) · Cochrane | no estimate extracted | 1 study · 31 participants | Very low |
Open surgical excision vs eccentric exercises Knee pain Scale from: 0 to 10 (0 is no pain) · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | 1 study · 40 participants | Low |
Arthroscopic surgery vs sclerosing injection Participant global assessment of success Scale from: 0 to 100 (higher is greater satisfaction) · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | 1 study · 50 participants | Low |
Arthroscopic surgery vs sclerosing injection Quality of life · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | NR | No studies |
Arthroscopic surgery vs sclerosing injection Withdrawal rate · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | 1 study · 40 participants | Very low |
Arthroscopic surgery vs sclerosing injection Adverse event · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | NR | No studies |
Arthroscopic surgery vs sclerosing injection Tendon rupture · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | NR | No studies |
Open surgical excision vs eccentric exercises Function Scale from: 0 to 100 (100 is best function) · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | 1 study · 40 participants | Low |
Open surgical excision vs eccentric exercises Participant global assessment of success (People who perceived their pain as none) · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | RR 0.71 [0.27, 1.88] | 1 study · 40 participants | Low |
Open surgical excision vs eccentric exercises Quality of life · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | NR | No studies |
Open surgical excision vs eccentric exercises Withdrawal rate · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | 1 study · 40 participants | Low |
Open surgical excision vs eccentric exercises Adverse event · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | 1 study · 40 participants | Very low |
Open surgical excision vs eccentric exercises Tendon rupture · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | NR | No studies |
Arthroscopic surgery vs sclerosing injection Knee pain Scale from: 0 to 100 (0 is no pain) · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | 1 study · 50 participants | Low |
Arthroscopic surgery vs sclerosing injection Function · adult participants with patellar tendinopathy Surgery for patellar tendinopathy (jumper’s knee) (2019) · Cochrane | no estimate extracted | NR | No studies |
Paracetamol vs placebo Mean change in pain (0–100 scale) Short term (3–12 weeks), where 0 = no pain · people with hip or knee osteoarthritis Paracetamol versus placebo for knee and hip osteoarthritis (2019) · Cochrane | no estimate extracted | 7 studies · 2355 participants | High |
Paracetamol vs placebo Physical function (WOMAC function 0–100) · people with hip or knee osteoarthritis Paracetamol versus placebo for knee and hip osteoarthritis (2019) · Cochrane | no estimate extracted | 7 studies · 2354 participants | High |
Paracetamol vs placebo Quality of life Not measured · people with hip or knee osteoarthritis Paracetamol versus placebo for knee and hip osteoarthritis (2019) · Cochrane | no estimate extracted | NR | No studies |
Paracetamol vs placebo Withdrawals due to adverse events 24 weeks · people with hip or knee osteoarthritis Paracetamol versus placebo for knee and hip osteoarthritis (2019) · Cochrane | RR 1.19 [0.91, 1.55] | 7 studies · 3023 participants | Moderate |
Paracetamol vs placebo Total adverse events: number experiencing 24 weeks · people with hip or knee osteoarthritis Paracetamol versus placebo for knee and hip osteoarthritis (2019) · Cochrane | RR 1.01 [0.92, 1.11] | 8 studies · 3252 participants | High |
Paracetamol vs placebo Liver toxicity: number experiencing abnormal liver function tests 24 weeks · people with hip or knee osteoarthritis Paracetamol versus placebo for knee and hip osteoarthritis (2019) · Cochrane | RR 3.79 [1.94, 7.39] | 3 studies · 1237 participants | Moderate |
Paracetamol vs placebo Serious adverse events: number experiencing 24 weeks · people with hip or knee osteoarthritis Paracetamol versus placebo for knee and hip osteoarthritis (2019) · Cochrane | RR 1.36 [0.73, 2.53] | 6 studies · 3209 participants | Moderate |
MX exercise training vs control HRQL FIQ Total. Scale from 0 to 100; high scores indicate worse quality of life Median length of interventions: 12 weeks · individuals with fibromyalgia Mixed exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | 13 studies · 610 participants | Moderate |
MX exercise training vs control Pain FIQ Pain, VAS, and SF‐36 Bodily Pain. Scale from 0 to 100; high scores indicate worse pain Median length of interventions: 12 weeks · individuals with fibromyalgia Mixed exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | 15 studies · 832 participants | Moderate |
MX exercise training vs control Fatigue FIQ Fatigue, VAS, and SF‐36 vitality. Scale from 0 to 100; high scores indicate worse fatigue Median length of interventions: 16 weeks · individuals with fibromyalgia Mixed exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | 11 studies · 493 participants | Moderate |
MX exercise training vs control Stiffness FIQ Stiffness and VAS. Scale from: 0 to 100; high scores indicate worse stiffness Median length of interventions: 12 weeks · individuals with fibromyalgia Mixed exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | 5 studies · 261 participants | Low |
MX exercise training vs control Physical function FIQ Physical Function, SF‐36 Physical Function, AIMS, and HAQ. Scale converted to 0 to 100; high scores indicate worse physical function Median length of interventions: 12 weeks · individuals with fibromyalgia Mixed exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | 9 studies · 477 participants | Moderate |
MX exercise training vs control All‐cause withdrawal All‐cause withdrawals from studies Median length of interventions: 16 weeks · individuals with fibromyalgia Mixed exercise training for adults with fibromyalgia (2019) · Cochrane | RR 1.02 [0.69, 1.51] | 19 studies · 1065 participants | Moderate |
MX exercise training vs control Adverse events ‐ increase in symptoms, injuries, or serious adverse events · individuals with fibromyalgia Mixed exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | NR | Very low |
Flexibility exercise training vs aerobic exercise training Health‐related quality of life · adults with fibromyalgia Flexibility exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | 2 studies · 193 participants | Very low |
Flexibility exercise training vs aerobic exercise training Pain intensity · adults with fibromyalgia Flexibility exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | 5 studies · 266 participants | Very low |
Flexibility exercise training vs aerobic exercise training Fatigue · adults with fibromyalgia Flexibility exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | 2 studies · 75 participants | Very low |
Flexibility exercise training vs aerobic exercise training Stiffness · adults with fibromyalgia Flexibility exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | 1 study · 15 participants | Very low |
Flexibility exercise training vs aerobic exercise training Physical function · adults with fibromyalgia Flexibility exercise training for adults with fibromyalgia (2019) · Cochrane | no estimate extracted | 1 study · 60 participants | Very low |