Findings

What do systematic reviews say?

276 questions · 290 findings · 42 reviews · Headline outcomes only

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No studies found 26 · 9%GRADE not reported 17 · 5.9%Very low 82 · 28.3%Low 92 · 31.7%Moderate 66 · 22.8%High 7 · 2.4%

SPRM vs leuprolide acetate

Quality of life: change in health‐related quality of life score · uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 281 participants
Moderate

SPRM vs leuprolide acetate

Abnormal uterine bleeding: change in menstrual blood loss · uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 281 participants
Low

Intervention not reported

Systolic blood pressure · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
47 studies · 5246 participants
Low

Intervention not reported

Diastolic blood pressure · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
48 studies · 5316 participants
Low

Intervention not reported

Heart rate · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
33 studies · 3407 participants
Low

Intervention not reported

Pulse pressure · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
47 studies · 5246 participants
Very low

Intervention not reported

WDAE · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 2618 participants
Low

SSRIs or SNRIs vs placebo

Migraine frequency Number of attacks · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 113 participants
Low

SSRIs or SNRIs vs amitriptyline

Migraine duration Hours · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 104 participants
Low

SSRIs or SNRIs vs amitriptyline

Symptomatic/analgesic medication use for acute headache attacks · patients for whom migraine preventive interventions are indicated

The review found no eligible studies for this question.

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SSRIs or SNRIs vs amitriptyline

Migraine index · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

SSRIs or SNRIs vs amitriptyline

Quality of life · patients for whom migraine preventive interventions are indicated

The review found no eligible studies for this question.

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SSRIs or SNRIs vs amitriptyline

Participants who withdraw because of an adverse event or any other reason · patients for whom migraine preventive interventions are indicated

SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
OR 0.39 [0.1, 1.5]
1 study · 64 participants
Low

SSRIs or SNRIs vs placebo

Migraine intensity Score · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 113 participants
Low

SSRIs or SNRIs vs placebo

Migraine duration Hours · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
GRADE not reported

SSRIs or SNRIs vs placebo

Symptomatic/analgesic medication use for acute headache attacks · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 113 participants
Low

SSRIs or SNRIs vs placebo

Migraine index · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 86 participants
Very low

SSRIs or SNRIs vs placebo

Quality of life · patients for whom migraine preventive interventions are indicated

The review found no eligible studies for this question.

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SSRIs or SNRIs vs placebo

Number withdrawn due to adverse events · patients for whom migraine preventive interventions are indicated

It is very uncertain whether SSRIs or SNRIs changes withdrawn (due to adverse events) compared with placebo (very low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
OR 1.95 [0.7, 5.44]
5 studies · 221 participants
Very low

SSRIs or SNRIs vs amitriptyline

Migraine frequency Number of attacks · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 96 participants
Very low