Disinhibition or excitation · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Discomfort/pain · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy
Intravenous midazolam showed no clear difference in discomfort/pain compared with diazepam (low certainty).
1 finding from 1 review
Allergic or anaphylactoid reaction · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Anxiety · adults requiring sedation before gastrointestinal endoscopy and bronchoscopy
1 finding from 1 review
Side effects or other adverse events · emergency department procedural sedation
1 finding from 1 review
Participant satisfaction (as defined by study authors) · emergency department procedural sedation
1 finding from 1 review
Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · emergency department procedural sedation
1 finding from 1 review
Duration of mechanical ventilation · Critically ill patients requiring long‐term sedation during mechanical ventilation
1 finding from 1 review
Risk of delirium · Critically ill patients requiring long‐term sedation during mechanical ventilation
It is very uncertain whether dexmedetomidine changes risk of delirium compared with traditional sedative agents (very low certainty).
1 finding from 1 review
Risk of coma · Critically ill patients requiring long‐term sedation during mechanical ventilation
It is very uncertain whether dexmedetomidine changes risk of coma compared with traditional sedative agents (very low certainty).
1 finding from 1 review
Bradycardia · Critically ill patients requiring long‐term sedation during mechanical ventilation
It is very uncertain whether dexmedetomidine changes incidence of bradycardia compared with traditional sedative agents (very low certainty).
1 finding from 1 review
Total duration of weaning defined as study randomization to successful extubation (hours) · Critically ill patients requiring long‐term sedation during mechanical ventilation
1 finding from 1 review
Duration of ICU stay · Critically ill patients requiring long‐term sedation during mechanical ventilation
1 finding from 1 review
All‐cause mortality · Critically ill patients requiring long‐term sedation during mechanical ventilation
It is very uncertain whether dexmedetomidine changes mortality compared with traditional sedative agents (very low certainty).
1 finding from 1 review
Intervention not reported
Total studies: 117 RCTs Total participants: 21,440 Number of treatments: 44 Geometry of the network** · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
Intervention not reported
Dolasetron (5 RCTs; 2402 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
Intervention not reported
Granisetron (9 RCTs; 850 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
Intervention not reported
Ondansetron (36 RCTs; 6092 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
Intervention not reported
Palonosetron (2 RCTs; 278 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
Intervention not reported
Ramosetron (5 RCTs; 581 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review