Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

286 questions · 318 findings · 37 reviews · Developmental, Psychosocial and Learning Problems

No studies found 53 · 16.7%GRADE not reported 19 · 6%Very low 84 · 26.4%Low 96 · 30.2%Moderate 60 · 18.9%High 6 · 1.9%

Fibre vs placebo

Improvement in pain: 0 to 3 months' postintervention Improvement in pain was defined and measured differently in the 2 included studies: using a "stomach ache diary" and the Faces Pain Scale (Bieri 1990). · Children with recurrent abdominal pain

Fibre showed no clear difference in improvement in pain: 0 to 3 months' postintervention Improvement in… compared with placebo (low certainty).

1 finding from 1 review

High‐dose methylphenidate vs placebo

Inattention Measured using SNAP‐IV inattention subscale (range 0 to 27) · Children aged 6 to 18 years with ASD
2 findings from 1 review

Simethicone vs placebo

Reduction in crying duration Difference between final values (hours per day of crying) · infants with colic defined by recognised criteria

It is very uncertain whether simethicone changes reduction in crying duration Difference between final values (hours… compared with placebo (very low certainty).

1 finding from 1 review

Simethicone vs placebo

Responders Number of infants who improved after treatment · infants with colic defined by recognised criteria

Simethicone showed no clear difference in responders Number of infants who improved after treatment compared with placebo (low certainty).

1 finding from 1 review

Herbal agents vs placebo

Reduction in crying duration Difference before and after treatment (hours per day of crying) · patients with infantile colic

Herbal agents may leads to higher reduction in crying duration Difference before and after treatment… compared with placebo (low certainty).

1 finding from 1 review

Herbal agents vs placebo

Responders Number of infants who improved after treatment · patients with infantile colic

Herbal agents probably leads to higher responders Number of infants who improved after treatment compared with placebo (moderate certainty).

1 finding from 1 review

Sugar vs placebo

Reduction in crying duration Difference before and after treatment (hours per day of crying) · infants with colic defined by recognised criteria

It is very uncertain whether sugar changes reduction in crying duration Difference before and after treatment… compared with placebo (very low certainty).

1 finding from 1 review

Cimetropium bromide vs placebo

Reduction in crying duration Difference between final values (minutes per crisis of crying) · infants with colic defined by recognised criteria

It is very uncertain whether cimetropium bromide changes reduction in crying duration Difference between final values… compared with placebo (very low certainty).

1 finding from 1 review