Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

275 questions · 298 findings · 28 reviews · Dementia and Cognitive Improvement

No studies found 47 · 15.8%GRADE not reported 9 · 3%Very low 45 · 15.1%Low 60 · 20.1%Moderate 104 · 34.9%High 33 · 11.1%

Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo

Progression to Alzheimer's disease Number of people progressing to AD · MCI

Vitamin E (capsules 2000 IU/day in two divided doses) showed no clear difference in progression to Alzheimer's disease Number of people progressing to AD compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Incidence of dementia · older people with normal cognitiona

Statins showed no clear difference in incidence of dementia Range of scale yes/no compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Cognitive function · older people with normal cognitiona

Statins showed no clear difference in mini Mental State Examination Score Score out of 30 (higher score… compared with placebo (high certainty).

1 finding from 1 review

Statins vs placebo

Stroop Colour Word Test Total number of seconds required to complete the third Stroop card containing 40 items Measures attention · older people with normal cognitiona

Statins showed no clear difference in stroop Colour Word Test Total number of seconds required to complete… compared with placebo (high certainty).

1 finding from 1 review

Statins vs placebo

Picture‐Word Learning Test 15 Picture Learning Test Measures immediate and delayed recall · older people with normal cognitiona

Statins showed no clear difference in picture‐Word Learning Test 15 Picture Learning Test Measures… compared with placebo (high certainty).

1 finding from 1 review

Statins vs placebo

Letter Digit Coding Test Total number of correct entries completed in 60 seconds Measures processing speed · older people with normal cognitiona

Statins showed no clear difference in letter Digit Coding Test Total number of correct entries completed… compared with placebo (high certainty).

1 finding from 1 review

Statins vs placebo

Mean Modified Telephone Interview for Cognitive Status Score Score out of 39 · older people with normal cognitiona

Statins showed no clear difference in mean Modified Telephone Interview for Cognitive Status Score Score… compared with placebo (high certainty).

1 finding from 1 review

Statins vs placebo

Discontinuation of medication due to adverse events · older people with normal cognitiona

Statins showed no clear difference in adverse events leading to discontinuation of therapy compared with placebo (high certainty).

1 finding from 1 review